CAJ | 학술논문

目的探讨周围型肺癌CT征象与E钙黏附蛋白(E-cad)表达间的关系. 方法本组58例周围型肺癌患者,均采用螺旋扫描.标本4 μm连续切片,采用免疫组织化学S-P法检测肿瘤组织E-cad的表达.实验数据经SPSS10.0统计软件包进行统计学处理. 结果 E-cad异常表达32例,细胞分化Ⅰ～Ⅱ级组和Ⅲ～Ⅳ级组阳性表达率分别为40.63%和73.08%,2组间比较差异具有统计学意义(P＜0.05).肺癌E-cad的异常表达与肿瘤的大小、棘突征、胸膜侵犯、淋巴转移明显相关(P<0.05).而与毛刺征、血管集中征、空洞征、胸膜凹陷征、分叶征无关(P>0.05). 结论 E-cad异常表达在肺癌的发生、发展及CT表现中可能起重要作用.
목적 탐토주위형폐암CT정상여E개점부단백(E-cad)표체간적관계. 방법 본조58례주위형폐암환자,균채용라선소묘.표본4 μm련속절편,채용면역조직화학S-P법검측종류조직E-cad적표체.실험수거경SPSS10.0통계연건포진행통계학처리. 결과 E-cad이상표체32례,세포분화Ⅰ～Ⅱ급조화Ⅲ～Ⅳ급조양성표체솔분별위40.63%화73.08%,2조간비교차이구유통계학의의(P＜0.05).폐암E-cad적이상표체여종류적대소、극돌정、흉막침범、림파전이명현상관(P<0.05).이여모자정、혈관집중정、공동정、흉막요함정、분협정무관(P>0.05). 결론 E-cad이상표체재폐암적발생、발전급CT표현중가능기중요작용.
Objective To investigate the correlation of spiral CT features with expression of E-cadherin(E-cad) in peripheral lung cancer.Methods Spiral CT scans were performed in 58 patients with peripheral lung cancer confirmed by pathology.Expression of E-cad in 58 cases were detected with SP immunohistochemical techniques.Spiral CT findings were compared with expression of E-cad.Results The abnormal expression of E-cad was showed in 32 cases(55.17%).The positive rates of E-cad expression were 40.63% in I-II cell differentiation group and 73.08% in III-IV cell differentiation group,and the difference was significant(P＜0.05).The abnormal expression of E-cad was associated with the CT features,such as lymph node metastasis,pleural invasion and the size of tumor(P＜0.05),but not the cavity sign,spicular sign and vessel convergence sign(P＞0.05).Conclusion E-cad gene over expression may play an important role in the pathogenesis and CT appearances of lung cancer.