CAJ | 학술논문

特应性皮炎的病因复杂,发病机制尚未明确,可能是遗传、环境、皮肤屏障功能缺陷及免疫相互作用的结果.中间丝蛋白基因是表皮分化复合物基因簇的成员之一,与细胞膜形成及表皮终末分化密切相关.中间丝蛋白基因突变是特应性皮炎发病的重要易患因素之一,中间丝蛋白的减少和缺失,可能是引起特应性皮炎等十燥性皮肤病的主要原因.
특응성피염적병인복잡,발병궤제상미명학,가능시유전、배경、피부병장공능결함급면역상호작용적결과.중간사단백기인시표피분화복합물기인족적성원지일,여세포막형성급표피종말분화밀절상관.중간사단백기인돌변시특응성피염발병적중요역환인소지일,중간사단백적감소화결실,가능시인기특응성피염등십조성피부병적주요원인.
The exact etiology and pathogenesis of atopic dermatitis (AD) have not yet been entirely elucidated.It may be the result of interaction between genetic factors,environmental factors,skin barrier defects and immunologic factors.Filaggrin gene is a member of epidermal difierentiation complex,and it closely relates to the formation of cell membrane and terminal differentiation of epidermis.It has been identified that filaggrin gene is a susceptibility gene for AD,and the defect and loss of filaggrin protein may be a major cause of xerotic skin diseases.