中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2008年
16期
19-21
,共3页
C反应蛋白质%磷酸丙酮酸水合酶%脑梗塞%神经功能损害
C反應蛋白質%燐痠丙酮痠水閤酶%腦梗塞%神經功能損害
C반응단백질%린산병동산수합매%뇌경새%신경공능손해
C-reactive protein%Phosphopyruvate hydratase%Brain infarction%Neurological impairment
目的 观察急性脑梗死(ACI)发病早期血清CRP和神经元特异性烯醇化酶(NSE)水平变化与病情严重程度的关系以及两者的相关关系.方法 检测60例ACI患者(ACI组)以及40例健康体检者(对照组)的血清CRP、NSE水平,采用美国国立卫生院卒中量表(NIHSS)对ACI患者入院时的临床神经功能损害程度进行评价,比较CRP、NSE水平在不同大小梗死灶及不同临床神经功能损害程度中的差异,并与对照组比较.结果 ACI组血清CRP、NSE水平与对照组比较显著增高[(6.95±2.34)mg/L比(2.21±1.05)mg/L,(22.39±4.72)μg/L比(7.16±2.63)μg/L,P均＜0.01].梗死灶越大、临床神经功能损害程度越重,血清CRP、NSE水平越高.血清CRP、NSE水平分别与NIHSS评分呈正相关(r=0.51、r=0.44,P均＜0.01).血清CRP水平与NSE水平呈正相关(r=0.57,P＜0.01).结论 ACI发病早期血清CRP、NSE水平变化可反映梗死灶大小和临床神经功能损害的严重程度.CRP、NSE水平均可作为ACI患者病情评估的重要生物学指标.
目的 觀察急性腦梗死(ACI)髮病早期血清CRP和神經元特異性烯醇化酶(NSE)水平變化與病情嚴重程度的關繫以及兩者的相關關繫.方法 檢測60例ACI患者(ACI組)以及40例健康體檢者(對照組)的血清CRP、NSE水平,採用美國國立衛生院卒中量錶(NIHSS)對ACI患者入院時的臨床神經功能損害程度進行評價,比較CRP、NSE水平在不同大小梗死竈及不同臨床神經功能損害程度中的差異,併與對照組比較.結果 ACI組血清CRP、NSE水平與對照組比較顯著增高[(6.95±2.34)mg/L比(2.21±1.05)mg/L,(22.39±4.72)μg/L比(7.16±2.63)μg/L,P均＜0.01].梗死竈越大、臨床神經功能損害程度越重,血清CRP、NSE水平越高.血清CRP、NSE水平分彆與NIHSS評分呈正相關(r=0.51、r=0.44,P均＜0.01).血清CRP水平與NSE水平呈正相關(r=0.57,P＜0.01).結論 ACI髮病早期血清CRP、NSE水平變化可反映梗死竈大小和臨床神經功能損害的嚴重程度.CRP、NSE水平均可作為ACI患者病情評估的重要生物學指標.
목적 관찰급성뇌경사(ACI)발병조기혈청CRP화신경원특이성희순화매(NSE)수평변화여병정엄중정도적관계이급량자적상관관계.방법 검측60례ACI환자(ACI조)이급40례건강체검자(대조조)적혈청CRP、NSE수평,채용미국국립위생원졸중량표(NIHSS)대ACI환자입원시적림상신경공능손해정도진행평개,비교CRP、NSE수평재불동대소경사조급불동림상신경공능손해정도중적차이,병여대조조비교.결과 ACI조혈청CRP、NSE수평여대조조비교현저증고[(6.95±2.34)mg/L비(2.21±1.05)mg/L,(22.39±4.72)μg/L비(7.16±2.63)μg/L,P균＜0.01].경사조월대、림상신경공능손해정도월중,혈청CRP、NSE수평월고.혈청CRP、NSE수평분별여NIHSS평분정정상관(r=0.51、r=0.44,P균＜0.01).혈청CRP수평여NSE수평정정상관(r=0.57,P＜0.01).결론 ACI발병조기혈청CRP、NSE수평변화가반영경사조대소화림상신경공능손해적엄중정도.CRP、NSE수평균가작위ACI환자병정평고적중요생물학지표.
Objective To investigate the changes of serum C-reactive protein(CRP)and neu-ron-specific enolase(NSE)levels in patients with acute cerebral infarction(ACI)and their relations with in farct size,severity of neurological impairment.Methods The levels of serum CRP,NSE were measured in 60 patients(ACI group)within 72 hours after infarction and 40 normal controls(control group).The severity of neurological impairment of patients with ACl was assessed by National Institutes of Health Stroke Scale (NIHSS)at admission.Results The mean levels of serum CRP and NSE in ACI group were higher than those in control group, (6.95±2.34)mg/L vs(2.21±1.05)mg/L,P＜0.01, (22.39±4.72)μg/L vs(7.16±2.63)μg/L,P＜0.01,respectively.Higher levels of CRP and NSE were obviously associated with larger infarct size and more severe neurological impairment.The changes of CRP and NSE levels correlated with scores of NIHSS(r=0.51,r=0.44,all P＜0.01)significantly.CRP levels were positively correlated with those of NSE(r=0.57,P＜0.01).Conclusion The levels of serum CRP and NSE can be used as an important biological marker to estimate the size of infarct and the severity of neurological impairment in ACI.
