中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2011年
6期
458-461
,共4页
林少俊%潘建基%韩露%陈传本%张瑜%陈奇松%林锦%张秀春
林少俊%潘建基%韓露%陳傳本%張瑜%陳奇鬆%林錦%張秀春
림소준%반건기%한로%진전본%장유%진기송%림금%장수춘
美国癌症研究联合会第7版分期系统%鼻咽肿瘤/二维放射疗法%鼻咽肿瘤/三维放射疗法%预后
美國癌癥研究聯閤會第7版分期繫統%鼻嚥腫瘤/二維放射療法%鼻嚥腫瘤/三維放射療法%預後
미국암증연구연합회제7판분기계통%비인종류/이유방사요법%비인종류/삼유방사요법%예후
American joint committee on cancer stage system%Nasopharyngeal neoplasm/two-dimensional radiotherapy%Nasopharyngeal neoplasm/three-dimensional radiotherapy%Prognosis
目的 观察美国癌症研究联合会( AJCC)第7版肿瘤分期标准对鼻咽癌常规放疗(CRT)和凋强放疗(IMRT)预后的影响.方法 用AJCC第7版肿瘤TNM分期标准对本院2004-2006年接受CRT和IMRT的鼻咽癌患者重新分期和分析预后.共1138例患者入组,CRT 790例,IMRT 348例.CRT和IMRT患者中位年龄分别为47岁和45岁(x2 =1.49,P=0.222),男女比例分别为580∶210和266∶82(x2=1.15,P=0.303),Ⅰ、Ⅱ、Ⅲ、Ⅳ期例数分别为0、41、488、261和5、65、176、102例(x2 =64.78,P=0.001).比较两种放疗的3年疗效,Kaplan-Meier法计算生存率并Logrank法检验.结果 3年随访率为96.0％.常规、IMRT患者中位随访时间分别为32、33个月,死亡例数分别为113、35例.N分期是影响常规、IMRT总生存和无远处转移生存的因素(x2 =6.50、13.60,P=0.038、0.004和X2=7.78、15.30,P=0.009、0.002),临床分期对CRT总生存有影响(x2=6.70,P=0.035)、对IMRT无远处转移生存有影响(x2=9.12,P=0.028).结论 第7版AJCCT分期仍不能满足准确判断鼻咽癌预后的需要,N分期是影响鼻咽癌总生存和无远处转移生存的重要预后因素.
目的 觀察美國癌癥研究聯閤會( AJCC)第7版腫瘤分期標準對鼻嚥癌常規放療(CRT)和凋彊放療(IMRT)預後的影響.方法 用AJCC第7版腫瘤TNM分期標準對本院2004-2006年接受CRT和IMRT的鼻嚥癌患者重新分期和分析預後.共1138例患者入組,CRT 790例,IMRT 348例.CRT和IMRT患者中位年齡分彆為47歲和45歲(x2 =1.49,P=0.222),男女比例分彆為580∶210和266∶82(x2=1.15,P=0.303),Ⅰ、Ⅱ、Ⅲ、Ⅳ期例數分彆為0、41、488、261和5、65、176、102例(x2 =64.78,P=0.001).比較兩種放療的3年療效,Kaplan-Meier法計算生存率併Logrank法檢驗.結果 3年隨訪率為96.0％.常規、IMRT患者中位隨訪時間分彆為32、33箇月,死亡例數分彆為113、35例.N分期是影響常規、IMRT總生存和無遠處轉移生存的因素(x2 =6.50、13.60,P=0.038、0.004和X2=7.78、15.30,P=0.009、0.002),臨床分期對CRT總生存有影響(x2=6.70,P=0.035)、對IMRT無遠處轉移生存有影響(x2=9.12,P=0.028).結論 第7版AJCCT分期仍不能滿足準確判斷鼻嚥癌預後的需要,N分期是影響鼻嚥癌總生存和無遠處轉移生存的重要預後因素.
목적 관찰미국암증연구연합회( AJCC)제7판종류분기표준대비인암상규방료(CRT)화조강방료(IMRT)예후적영향.방법 용AJCC제7판종류TNM분기표준대본원2004-2006년접수CRT화IMRT적비인암환자중신분기화분석예후.공1138례환자입조,CRT 790례,IMRT 348례.CRT화IMRT환자중위년령분별위47세화45세(x2 =1.49,P=0.222),남녀비례분별위580∶210화266∶82(x2=1.15,P=0.303),Ⅰ、Ⅱ、Ⅲ、Ⅳ기례수분별위0、41、488、261화5、65、176、102례(x2 =64.78,P=0.001).비교량충방료적3년료효,Kaplan-Meier법계산생존솔병Logrank법검험.결과 3년수방솔위96.0％.상규、IMRT환자중위수방시간분별위32、33개월,사망례수분별위113、35례.N분기시영향상규、IMRT총생존화무원처전이생존적인소(x2 =6.50、13.60,P=0.038、0.004화X2=7.78、15.30,P=0.009、0.002),림상분기대CRT총생존유영향(x2=6.70,P=0.035)、대IMRT무원처전이생존유영향(x2=9.12,P=0.028).결론 제7판AJCCT분기잉불능만족준학판단비인암예후적수요,N분기시영향비인암총생존화무원처전이생존적중요예후인소.
Objective To compare the prognostic value of the 7th edition of AJCC cancer staging system in nasopharyngeal carcinoma (NPC) patients treated with conventional radiotherapy (CRT) and intensity-modulated radiotherapy (IMRT).Methods From January 2004 to December 2006,totally 1138 NPC patients were treated with CRT (790 patients) and IMRT (348 patients) in Cancer Hospital of Fujian province.The median ages were 47 and 45 years old for two groups ( x2 =1.49,P =0.222 ),respectively.There were 0,41,488,261 and 5,65,176,102 patients in stage Ⅰ,Ⅱ,Ⅲ,Ⅳ of the two groups after restaged with 7th edition of AJCC cancer staging system,respectively (x2 =64.78,P =0.001 ).The 3-year survival was analyzed according to T-category,N-category and overall stage.Results The follow-up rate at 3 years is 96.0％.The median follow-up were 32 months and 33 months for CRT and IMRT groups.N-category was found to be the prognostic factors for overall survival (OS,x2 =6.50,P =0.038 and x2 =13.60,P =0.004) and metastasis free survival ( MFS,x2 =7.78,P =0.009 and x2 =15.30,P =0.002) for CRT and IMRT groups.The clinical stage was prognostic factor for OS in conventional group ( x2 =6.70,P=0.035),and for MFS in IMRT group (x2 =9.12,P=0.028).Conclusions The T-calegory of 7th AJCC staging system shows poor predictive value for the long-term survival of NPC patients.The N-calegory of 7th AJCC staging system can well estimate the OS and MFS for NPC.
