国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2009年
1期
18-21,封3
,共5页
聚乙烯醇%壳聚糖%胶原%组织工程%支架
聚乙烯醇%殼聚糖%膠原%組織工程%支架
취을희순%각취당%효원%조직공정%지가
Polyvinyl alcohol%Chitosan%Collagen%Tissue engineering%Scaffold
目的 以聚乙烯醇(PVA)、壳聚糖(Cs)和胶原(Col)为主要原料制备PVA-Cs-Col复合支架,并研究其作为组织工程支架材料的可行性.方法 把聚乙烯醇、壳聚糖和胶原按一定配比复合,测定复合材料的含水率、膨胀率和力学性能,扫描电镜观察材料横截面的组织形态.结果 不同分子量PVA与不同质垣的Cs和Col复合,得到的复合支架材料湿态抗张强度为5.70 MPa,含水率在60.15%～72.50%,膨胀率在185.33%～317.57%.不同配比的复合支架具有不同的内部组织形态结构.结论 PVA-Cs-Col复合支架材料具有较高的含水率和适宜的膨胀率,内部孔洞丰富,Cs:PVA:Col的质量比为30:15:0.20时,复合支架综合性能较佳,适合用于组织工程支架材料.
目的 以聚乙烯醇(PVA)、殼聚糖(Cs)和膠原(Col)為主要原料製備PVA-Cs-Col複閤支架,併研究其作為組織工程支架材料的可行性.方法 把聚乙烯醇、殼聚糖和膠原按一定配比複閤,測定複閤材料的含水率、膨脹率和力學性能,掃描電鏡觀察材料橫截麵的組織形態.結果 不同分子量PVA與不同質垣的Cs和Col複閤,得到的複閤支架材料濕態抗張彊度為5.70 MPa,含水率在60.15%～72.50%,膨脹率在185.33%～317.57%.不同配比的複閤支架具有不同的內部組織形態結構.結論 PVA-Cs-Col複閤支架材料具有較高的含水率和適宜的膨脹率,內部孔洞豐富,Cs:PVA:Col的質量比為30:15:0.20時,複閤支架綜閤性能較佳,適閤用于組織工程支架材料.
목적 이취을희순(PVA)、각취당(Cs)화효원(Col)위주요원료제비PVA-Cs-Col복합지가,병연구기작위조직공정지가재료적가행성.방법 파취을희순、각취당화효원안일정배비복합,측정복합재료적함수솔、팽창솔화역학성능,소묘전경관찰재료횡절면적조직형태.결과 불동분자량PVA여불동질원적Cs화Col복합,득도적복합지가재료습태항장강도위5.70 MPa,함수솔재60.15%～72.50%,팽창솔재185.33%～317.57%.불동배비적복합지가구유불동적내부조직형태결구.결론 PVA-Cs-Col복합지가재료구유교고적함수솔화괄의적팽창솔,내부공동봉부,Cs:PVA:Col적질량비위30:15:0.20시,복합지가종합성능교가,괄합용우조직공정지가재료.
Objective To fabricate a novel polyvinyl alcohol (PVA)-chitosan(Cs)-collagen (Col) composite material and to confirm the feasibility of its application as a scaffold in tissue engineering.Methods PVA was blended with chitosan and collagen.The water content,swelling ratio,and tensile strength of the scaffolds were tested.SEM was used to observe the histological modality of the cross section.Results Scaffolds which al'e composite with different molecular weight and different amount of Cs and Collagen ale made,with water content ranging from 60.15% to 72.50% and swelling ratio being from 185.33% to 317.57%.The tensile strength of the composite material is 5.70MPa.The inner modality and structure of the scaffolds varied as the proportion of the chemical components changed.Conclusion PVA-Cs-Col scaffolds have high water content and proper swelling ratio and ale rich in porous structure.When the blending proportion is Cs:PVA:COI=30:15:0.20,the scaffold performs best,which shows to be a suitable structure for tissue engineering scaffold.
