中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2011年
7期
550-554
,共5页
樊晓红%蔡建芳%高碧霞%牟利军%李金红%刘雪姣%吴俊雪%孟庆艳%王海云%刘莉莉%李航%李雪梅%李学旺
樊曉紅%蔡建芳%高碧霞%牟利軍%李金紅%劉雪姣%吳俊雪%孟慶豔%王海雲%劉莉莉%李航%李雪梅%李學旺
번효홍%채건방%고벽하%모리군%리금홍%류설교%오준설%맹경염%왕해운%류리리%리항%리설매%리학왕
尿酸%危险因素%尿白蛋白排泄率%调查%北京
尿痠%危險因素%尿白蛋白排洩率%調查%北京
뇨산%위험인소%뇨백단백배설솔%조사%북경
Uric acid%Risk factor%Urinary albumin excretion%Survey%Beijing
目的 探讨普通人群中尿白蛋白排泄率(UAE)与血尿酸之间的关系.方法 对象来自于北京市平谷区代谢综合征肾损害流行病学调查的受试者,共992例(男463例、女529例).留取8 h过夜尿且行问卷调查、体格检查和实验室检查.结果 (1)微量白蛋白尿患病率为12.9%,临床蛋白尿患病率为1.8%,高尿酸血症患病率为4.3%.高尿酸血症组的UAE异常比例(37.2%)明显高于尿酸正常组(13.7%,P＜0.01).(2)根据血尿酸水平的四分位数(25%、50%、75%)将受试者分成4组,男性中UAE异常比例分别为13.2%、13.9%、17.2%、25.4%,女性中UAE异常比例分别为8.4%、6.2%、9.6%、24.8%.(3)多因素logistic回归显示血尿酸为女性对象UAE升高的独立危险因素(OR=2.31,95%CI1.15～4.68;P=0.02),而男性中未见血尿酸的明显作用.除外肾功能下降受试者后,仍可得到类似结果.结论 随着血清尿酸水平的升高,UAE异常的患病率逐渐增加,血尿酸水平是UAE升高的独立危险因素,该危险性在女性人群中更为明显.
目的 探討普通人群中尿白蛋白排洩率(UAE)與血尿痠之間的關繫.方法 對象來自于北京市平穀區代謝綜閤徵腎損害流行病學調查的受試者,共992例(男463例、女529例).留取8 h過夜尿且行問捲調查、體格檢查和實驗室檢查.結果 (1)微量白蛋白尿患病率為12.9%,臨床蛋白尿患病率為1.8%,高尿痠血癥患病率為4.3%.高尿痠血癥組的UAE異常比例(37.2%)明顯高于尿痠正常組(13.7%,P＜0.01).(2)根據血尿痠水平的四分位數(25%、50%、75%)將受試者分成4組,男性中UAE異常比例分彆為13.2%、13.9%、17.2%、25.4%,女性中UAE異常比例分彆為8.4%、6.2%、9.6%、24.8%.(3)多因素logistic迴歸顯示血尿痠為女性對象UAE升高的獨立危險因素(OR=2.31,95%CI1.15～4.68;P=0.02),而男性中未見血尿痠的明顯作用.除外腎功能下降受試者後,仍可得到類似結果.結論 隨著血清尿痠水平的升高,UAE異常的患病率逐漸增加,血尿痠水平是UAE升高的獨立危險因素,該危險性在女性人群中更為明顯.
목적 탐토보통인군중뇨백단백배설솔(UAE)여혈뇨산지간적관계.방법 대상래자우북경시평곡구대사종합정신손해류행병학조사적수시자,공992례(남463례、녀529례).류취8 h과야뇨차행문권조사、체격검사화실험실검사.결과 (1)미량백단백뇨환병솔위12.9%,림상단백뇨환병솔위1.8%,고뇨산혈증환병솔위4.3%.고뇨산혈증조적UAE이상비례(37.2%)명현고우뇨산정상조(13.7%,P＜0.01).(2)근거혈뇨산수평적사분위수(25%、50%、75%)장수시자분성4조,남성중UAE이상비례분별위13.2%、13.9%、17.2%、25.4%,녀성중UAE이상비례분별위8.4%、6.2%、9.6%、24.8%.(3)다인소logistic회귀현시혈뇨산위녀성대상UAE승고적독립위험인소(OR=2.31,95%CI1.15～4.68;P=0.02),이남성중미견혈뇨산적명현작용.제외신공능하강수시자후,잉가득도유사결과.결론 수착혈청뇨산수평적승고,UAE이상적환병솔축점증가,혈뇨산수평시UAE승고적독립위험인소,해위험성재녀성인군중경위명현.
Objective To investigate the relationship between the urinary albumin excretion (UAE) and serum uric acid in general population. Methods The study participants were derived from the epidemiological study on the association of metabolic syndrome and chronic kidney disease (CKD) in Pinggu district, Beijing. A total of 992 participants (463 men and 529 women) aged from 30 to 75 years were enrolled in this study. For each participant, UAE, serum uric acid, serum creatinine, and serum lipids were detected and other potential risk factors for CKD were surveyed. Results ( 1 ) The frequencies of microalbuminuria, macroalbuminuria and hyperuricemia were 12.9% , 1.8% and 4.3% respectively. The persons with hyperuricemia had significantly higher frequency of albuminuria than those without hyperuricemia (37. 2% vs 13. 7% , P ＜0. 01). (2) The participants were divided according to the quartiles (25% , 50% , 75% ) of serum uric acid level, and the frequencies of albuminuria in males were 13. 2% , 13. 9% , 17. 2% and 25.4% , while those in females were 8. 4% , 6. 2% , 9. 6% and 24. 8%. ( 3 ) Multivariate logistic regression analysis showed, hyperuricemia was significantly associated with albuminuria in females (OR =2. 31, 95% CI 1. 15-4. 68; P=0.02), but not in males. If the persons with reduced renal function were excluded, similar result still could be gained. Conclusions The prevalence of albuminuria increases gradually with uric acid elevation. Serum uric acid is an independent risk factor of elevated UAE, especially in females.
