CAJ | 학술논문

目的探讨低水平锰接触对焊工血清神经内分泌激素水平的影响.方法选择广西某厂41名男性焊工为接触组,某单位不接触锰烟尘及其他有害物质的40名男性工人为对照组,采用化学发光免疫法测定血清中催乳素(PRL)、促黄体生成素(LH)、尿促卵泡素(FSH)、睾酮(TST)、促甲状腺激素(TSH)含量.结果焊工作业环境空气MnO2几何平均浓度为0.03 mg/m3(0.003～0.519 mg/m3),接触组红细胞锰和尿锰明显高于对照组,差异均有统计学意义(P＜0.01).接触组血清LH、TSH水平[(2.89±0.69)mIU/ml、(1.45±0.56)μIU/ml]明显低于对照组[(3.82±1.61)mIU/ml、(2.19±1.28)μIU/ml],差异均有统计学意义(P＜0.01).接锰工龄＜5年组血清LH、FSH、TSH水平明显低于对照组,TST水平明显高于对照组和5～年组,FSH明显低于≥10年组,差异均有统计学意义(P＜0.05,P＜0.01).接锰工龄5～年组血清LH、TSH水平明显低于对照组,差异均有统计学意义(P＜0.05或P＜0.01);接锰工龄≥10年组血清PRL、LH、TSH水平明显低于对照组,差异均有统计学意义(P＜0.05).红细胞锰与尿锰呈负相关(r=-0.310,P＜0.05),血清PRL与TST呈负相关(r=-0.409,P＜0.01),LH与FSH正相关(r=0.361,P＜0.05).结论长期低水平锰接触可能会致工人血清PRL、LH和TSH水平下降,对神经内分泌激素代谢产生一定的影响.
목적 탐토저수평맹접촉대한공혈청신경내분비격소수평적영향.방법 선택엄서모엄41명남성한공위접촉조,모단위불접촉맹연진급기타유해물질적40명남성공인위대조조,채용화학발광면역법측정혈청중최유소(PRL)、촉황체생성소(LH)、뇨촉란포소(FSH)、고동(TST)、촉갑상선격소(TSH)함량.결과 한공작업배경공기MnO2궤하평균농도위0.03 mg/m3(0.003～0.519 mg/m3),접촉조홍세포맹화뇨맹명현고우대조조,차이균유통계학의의(P＜0.01).접촉조혈청LH、TSH수평[(2.89±0.69)mIU/ml、(1.45±0.56)μIU/ml]명현저우대조조[(3.82±1.61)mIU/ml、(2.19±1.28)μIU/ml],차이균유통계학의의(P＜0.01).접맹공령＜5년조혈청LH、FSH、TSH수평명현저우대조조,TST수평명현고우대조조화5～년조,FSH명현저우≥10년조,차이균유통계학의의(P＜0.05,P＜0.01).접맹공령5～년조혈청LH、TSH수평명현저우대조조,차이균유통계학의의(P＜0.05혹P＜0.01);접맹공령≥10년조혈청PRL、LH、TSH수평명현저우대조조,차이균유통계학의의(P＜0.05).홍세포맹여뇨맹정부상관(r=-0.310,P＜0.05),혈청PRL여TST정부상관(r=-0.409,P＜0.01),LH여FSH정상관(r=0.361,P＜0.05).결론 장기저수평맹접촉가능회치공인혈청PRL、LH화TSH수평하강,대신경내분비격소대사산생일정적영향.
Objective To study the effects of low level manganese (Mn)exposure on the serum neuroendocrine hormones levels of the welders. Methods The exposure group consisted of 41 male welders,40 male workers without exposing to harmful agents served as controls. The serum contents of prolactin(PRL),luteinizing hormone (LH), follicle stimulating hormone (FSH), testosterone (TST) and thyroid stimulating hormone (TSH) of 81 subjects were detected by chemiluminescence immunoassay. Results The geometric mean value of airborne Mn concentrations was 0.03 mg/m3 (0.003-0.519 mg/m3) in the welding circumstances.The levels of Mn in red blood cells(RBCs) and urinary Mn of the exposure group were significantly higher than those of control group ( P＜0.01 ). The contents of serum LH and TSH of the exposure group were 2.89±0.69mIU/ml and 1.45±0.56 uIU/ml, which were significantly lower than those (3.82±1.61 mIU/ml and 2.19±1.28μIU/ml ) of control group(P＜0.01 ). The serum contents of LH, FSH and TSH of the group exposed to Mn for ＜5years were significantly lower than those of the control group, The serum TST level of the group exposed to Mn for ＜5 years was significantly higher than those of the control group and group exposed to Mn for 5～years, the serum FSH level of the group exposed to Mn for ＜ 5 years was significantly lower than that of the group exposed to Mn for 10 years (P＜0.05 or P＜0.01 ). The serum contents of LH and TSH of the group exposed to Mn for 5～years were significantly lower than those of the control group (P＜0.05 or P＜0.01 ). The serum contents of PRL, LH and TSH of the group exposed to Mn for 10 years were significantly lower than those of the control group(P＜0.05 ). There was negative correlation between blood( RBC ) Mn and urinary Mn(r=-0.310, P＜0.05 ),also there was negative correlation between serum PRL and serum TST (r=-0.409, P＜0.01 ), the positive correlation between serum LH and serum FSH was observed (r=0.361, P＜0.05 ). Conclusion The results of present study showed that the long exposure to low level of Mn may decrease the levels of serum PRL, LH and TSH in workers occupationally exposed to Mn, which can influence the metabolism of neuroendocrine hormones to certain extent.