CAJ | 학술논문

实验研究了1.17 MHz的连续超声波作用下,人及鸡的血红细胞的溶血率、渗透脆性及膜脂过氧化水平的变化.结果表明,在声压较低时,流体间的剪切张力使得红细胞的溶血率、渗透脆性、脂质过氧化水平随作用时间及作用强度增加缓慢增长;但当声压超过空化阈值时,红细胞的溶血率随作用时间及作用强度的增加而显著增大,直至血红素完全释放细胞完全破裂;鸡红细胞的空化阈值明显高于人红细细胞,空化阈值不仅与声学参数有关,还与细胞体积和结构有关.
실험연구료1.17 MHz적련속초성파작용하,인급계적혈홍세포적용혈솔、삼투취성급막지과양화수평적변화.결과표명,재성압교저시,류체간적전절장력사득홍세포적용혈솔、삼투취성、지질과양화수평수작용시간급작용강도증가완만증장;단당성압초과공화역치시,홍세포적용혈솔수작용시간급작용강도적증가이현저증대,직지혈홍소완전석방세포완전파렬;계홍세포적공화역치명현고우인홍세세포,공화역치불부여성학삼수유관,환여세포체적화결구유관.
Under the 1.17 MHz continuous-wave ultrasound exposure, we make experimental comparisons of hemolysis, osmotic fragility and lipid peroxidation for both human erythrocyte and chicken erythrocyte dilute suspensions. Results demonstrate that ultrasound exposure at low sound intensities leads to slight increases in hemolysis, osmotic fragility and lipid peroxidation due to the effect of shear stress. However, a significant increase of hemolysis and even rupture of cell can be observed as the ultrasound intensity exceeds the cavitation threshold. The level of the cavitation threshold for chicken erythrocyte suspensions is higher than that for human red cell suspensions, suggesting that the cavitation threshold is associated with not only acoustic irradiation parameters, but also cell size and structure.