浙江预防医学
浙江預防醫學
절강예방의학
ZHEJIANG JOURNAL OF PREVENTIVE MEDICINE
2009年
3期
10-12
,共3页
黄妙珍%付珍春%陈兆军%朱善济%王祖武
黃妙珍%付珍春%陳兆軍%硃善濟%王祖武
황묘진%부진춘%진조군%주선제%왕조무
脂肪肝%脂质代谢%丹参%古拉啶%肿瘤坏死因子α
脂肪肝%脂質代謝%丹參%古拉啶%腫瘤壞死因子α
지방간%지질대사%단삼%고랍정%종류배사인자α
Fatty liver%Lipid metabolism%Salvia%Glutathione%TNF-α
目的 探讨丹参联合古拉啶对脂肪肝大鼠脂质代谢和TNF-α水平的影响.方法 用高脂饲料建立大鼠非酒精性脂肪肝模型,并用丹参注射液联合古拉啶溶液进行治疗,观察药物对脂质代谢和TNF-α的影响.结果 丹参注射液降低血清中MDA水平,联合用药降低组织中MDA水平,古拉啶溶液升高组织中SOD水平,血清中TNF-α水平上升,用药后无显著差异.结论 丹参注射液、古拉啶溶液及联合用药均具改善脂质过氧化作用.
目的 探討丹參聯閤古拉啶對脂肪肝大鼠脂質代謝和TNF-α水平的影響.方法 用高脂飼料建立大鼠非酒精性脂肪肝模型,併用丹參註射液聯閤古拉啶溶液進行治療,觀察藥物對脂質代謝和TNF-α的影響.結果 丹參註射液降低血清中MDA水平,聯閤用藥降低組織中MDA水平,古拉啶溶液升高組織中SOD水平,血清中TNF-α水平上升,用藥後無顯著差異.結論 丹參註射液、古拉啶溶液及聯閤用藥均具改善脂質過氧化作用.
목적 탐토단삼연합고랍정대지방간대서지질대사화TNF-α수평적영향.방법 용고지사료건립대서비주정성지방간모형,병용단삼주사액연합고랍정용액진행치료,관찰약물대지질대사화TNF-α적영향.결과 단삼주사액강저혈청중MDA수평,연합용약강저조직중MDA수평,고랍정용액승고조직중SOD수평,혈청중TNF-α수평상승,용약후무현저차이.결론 단삼주사액、고랍정용액급연합용약균구개선지질과양화작용.
Objective Tostudy the combination effects of salvia and glutathione on the levels of lipid metabolism and TNF-α in rats with nonalcoholic fatty liver.Methods The model rats with nonalcoholic fatty liver were made by feeding high fat forage. Fatty liver rats were randomly divided into model group, SI group, GL group and combined treatment group. The effect was observed after treatment. Results Compared with model group, the serum level of Malondialdehyde (MDA) in SI group and tissue MDA in combined group is lower, tissue SOD and TNF-α in serum is higher in GL group.Conclusions SI, GL and combined treatment could improve lipid peroxidation.
