CAJ | 학술논문

奥拉西坦是一种改善脑功能药物.该文研究了该药的核磁共振波谱特征和构象.吡咯环的各项异性效应使侧链亚甲基的质子的磁不等价.由于吡咯环内酰胺键的部分双键性质, 观测到了远程耦合现象.信封式构象为吡咯环的优势构象.同时研究了环外侧链上的酰胺键的受阻旋转.
오랍서탄시일충개선뇌공능약물.해문연구료해약적핵자공진파보특정화구상.필각배적각항이성효응사측련아갑기적질자적자불등개.유우필각배내선알건적부분쌍건성질, 관측도료원정우합현상.신봉식구상위필각배적우세구상.동시연구료배외측련상적선알건적수조선전.
Oxiracetam is often used as a nootropic agent.In this study, the NMR characteristics and conformation of oxiracetam were investigated.It was shown that the protons on the side-chain methylene group are magnetic nonequivalent because of the anisotropy effect of pyrrolidine ring.H6 and H3 showed long-range coupling, due to the partial double-bond character of the amide bond on the pyrrolidine ring.Pyrrolidine ring favored envelope conformation.Hindered internal rotation of another amide bond on the side chain was also analyzed.