CAJ | 학술논문

目的探讨米非司酮对子宫腺肌病异位病灶组织B-内啡肽表达的影响及其与痛经的关系.方法应用免疫组化法检测子宫腺肌病异位病灶组织中β-内啡肽的表达.结果轻度痛经组异位内膜组织β-内啡肽在增生期和分泌期的表达水平均高于中度痛经组(t=2.672、2.711,均P＜0.05),中度痛经组异位内膜组织β-内啡肽在增生期和分泌期的表达水平均高于重度痛经组(t=2.341、2.365,均P＜0.05).米非司酮治疗后,子宫腺肌病异位内膜组织β-内啡肽在增生期和分泌期的表达均高于子宫腺肌病对照组(t=2.478、2.356,均P＜0.05),但均低于正常子宫内膜(t=2.123、2.233,均P＜0.05).结论子宫腺肌病异位病灶中β-内啡肽的表达随着痛经程度的加重而下降,米非司酮可以升调β-内啡肽,缓解痛经.
목적 탐토미비사동대자궁선기병이위병조조직B-내배태표체적영향급기여통경적관계.방법 응용면역조화법검측자궁선기병이위병조조직중β-내배태적표체.결과 경도통경조이위내막조직β-내배태재증생기화분비기적표체수평균고우중도통경조(t=2.672、2.711,균P＜0.05),중도통경조이위내막조직β-내배태재증생기화분비기적표체수평균고우중도통경조(t=2.341、2.365,균P＜0.05).미비사동치료후,자궁선기병이위내막조직β-내배태재증생기화분비기적표체균고우자궁선기병대조조(t=2.478、2.356,균P＜0.05),단균저우정상자궁내막(t=2.123、2.233,균P＜0.05).결론 자궁선기병이위병조중β-내배태적표체수착통경정도적가중이하강,미비사동가이승조β-내배태,완해통경.
Objective To investigate the effect of mifepristone on the expression of β-endorphin in the ectopic focus of adenomyosis.Methods The expression of β-endorphin was measured by the immunochemistry method.Results During proliferative phase and secretory phase,the β-endorphin of mild dysmenorrhea were higher than that of midrange dysmenorrhea(t=2.672,2.711,all P＜0.05),the β-endorphin of midrange dysmenorrhea was higher than that of severe dysmenorrhea(t=2.341,2.365,all P＜0.05),the difference was significant.After being cured by mifepfistone,the expression of β-endorphin in the ectopic focus of adenomyosis was higher than that of control group (t=2.478,2.356,all P＜0.05),still lower than that of normal endometrial tissue,(t=2.123,2.233,all P＜0.05),the difference was significant.Conclusion The expression of β-endorphin in the ectopic focus of adenomyosis decreased significandy accompanied with the aggravation of the dysmenorrhea,and the mifepfistone could upregulate the β-endorphin and relieve the dysmenorrhea.