CAJ | 학술논문

目的探讨78例癫痫患者的丙戊酸钠血药浓度,为临床丙戊酸钠的合理使用提供参考依据.方法采用荧光偏振免疫法(FPIA)测定78例癫痫患者服用丙戊酸钠后的血药浓度值,并观察其临床疗效和不良反应.结果 78例癫痫患者丙戊酸钠血药浓度在治疗窗(50～100 mg/L)内的有55例,占总监测次数的70.0%,临床总有效率90.9%,1例患者出现不良反应发生率1.8%;浓度低于50 mg/L的患者共21例,占总监测例次的27.0%,临床总有效率61.9%,不良反应发生率9.5%;浓度高于100 mg/L的患者共2例,占总监测例次的3.0%,临床有效率50.0%,而不良反应发生率100.0%.结论丙戊酸钠的血药浓度监测可为临床医生制定个体化给药方案提供客观依据,对提高癫痫治疗的安全性、有效性有重要意义.
목적 탐토78례전간환자적병무산납혈약농도,위림상병무산납적합리사용제공삼고의거.방법 채용형광편진면역법(FPIA)측정78례전간환자복용병무산납후적혈약농도치,병관찰기림상료효화불량반응.결과 78례전간환자병무산납혈약농도재치료창(50～100 mg/L)내적유55례,점총감측차수적70.0%,림상총유효솔90.9%,1례환자출현불량반응발생솔1.8%;농도저우50 mg/L적환자공21례,점총감측례차적27.0%,림상총유효솔61.9%,불량반응발생솔9.5%;농도고우100 mg/L적환자공2례,점총감측례차적3.0%,림상유효솔50.0%,이불량반응발생솔100.0%.결론 병무산납적혈약농도감측가위림상의생제정개체화급약방안제공객관의거,대제고전간치료적안전성、유효성유중요의의.
Objective To explore the monitoring results on serum concentration of valproic acid in 78 patients with epilepsy for promoting the clinical application and improving the curative effect of serum concentration.Methods The serum concentration of valproic acid was determined by fluorescence polarization immunoassay (FPIA). The serum concentration of valproic acid in 78 cases were analyzed,and the clinical efficacy and adverse reaction were observed. Results Among 78 cases, there were 55 cases (70.0%) whose serum concentration were in normal range,21 cases(27.0% ) in low range and 2 cases(3. 0% ) in high range. The clinical effective rate in 50～100mg/L group, ＜ 50mg/L group and ＞ 100mg/L group were 90.9% ,61.9% and 50.0%. The rate of adverse reaction in 50 ～ 100mg/L group, ＜ 50mg/L group and ＞ 100mg/L group were 1. 8%, 9. 5% and 100%.Conclusion There were significant individual differences among patients in serum concentration of valproic acid. Monitoring on serum concentration of valproic acid was the important measure which provide the basis for adopting individualizede administration and ensure the clinical effect and safety in the medical care.