CAJ | 학술논문

探讨不同剂量阿托泛他汀对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)患者外周血可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)的影响.方法:选择因冠脉狭窄病变需行PCI的不稳定心绞痛30例,陈旧性心肌梗死10例,随机分为强化调脂组和常规调脂组,术后分别给予阿托伐他汀20 mg/d和10 mg/d;测定术前,术后3个月血脂(TC,TG,LDL-C,HDL-C)以及术前,术后48 h,术后3个月sICAM-1的变化.结果:术后3个月两组TC和LDL-C显著下降(P＜0.01),且强化调脂组较常规调脂组下降更显著(P＜0.01),而HDL-C和TG改变不显著(P＞0.05);术后48 h,两组sICAM-1均较术前显著升高(P＜0.01),而术后3月两组sICAM-1均较术前显著下降(P＜0.01,或P＜0.05),且强化调脂组较常规调脂组下降更显著(P＜0.01);TC与sICAM-1呈正相关,(r=0.2413,P＜0.05),LDL-C与sICAM-1也呈正相关(r=0.2691,P＜0.05).结论:强化调脂治疗比常规调脂治疗更能显著降低PCI患者术后TC,LDL-C和sICAM-1水平,其降低sICAM-1水平可能与降脂治疗有一定关系.
탐토불동제량아탁범타정대경피관상동맥개입치료(percutaneous coronary intervention,PCI)환자외주혈가용성세포간점부분자-1(soluble intercellular adhesion molecule-1,sICAM-1)적영향.방법:선택인관맥협착병변수행PCI적불은정심교통30례,진구성심기경사10례,수궤분위강화조지조화상규조지조,술후분별급여아탁벌타정20 mg/d화10 mg/d;측정술전,술후3개월혈지(TC,TG,LDL-C,HDL-C)이급술전,술후48 h,술후3개월sICAM-1적변화.결과:술후3개월량조TC화LDL-C현저하강(P＜0.01),차강화조지조교상규조지조하강경현저(P＜0.01),이HDL-C화TG개변불현저(P＞0.05);술후48 h,량조sICAM-1균교술전현저승고(P＜0.01),이술후3월량조sICAM-1균교술전현저하강(P＜0.01,혹P＜0.05),차강화조지조교상규조지조하강경현저(P＜0.01);TC여sICAM-1정정상관,(r=0.2413,P＜0.05),LDL-C여sICAM-1야정정상관(r=0.2691,P＜0.05).결론:강화조지치료비상규조지치료경능현저강저PCI환자술후TC,LDL-C화sICAM-1수평,기강저sICAM-1수평가능여강지치료유일정관계.