CAJ | 학술논문

目的观察加味青麟丸对老龄大鼠体质量和学习记忆能力的影响.方法选用Wistar大鼠120只,随机分为6组:4月龄空白对照组(4C组)、14月龄空白对照组(14C组)、14月龄加味青麟丸组(14JL组)、24月龄空白对照组(24C组)、24月龄加味青麟丸组(24JL组)和14～24月龄加味青麟丸组(14～24JL组),每组各20只,雌雄各半.各组均按实验设计要求分别喂养后,比较各组大鼠的一般情况及体质量,采用跳台实验检测各组大鼠学习、记忆能力.结果 14JL组与14C组比较差异有显著性:大鼠体质量增长慢[(315.28±20.35)g,(335.90±15.08)g,P<0.01],跳台实验中遭受电击次数少(P<0.01),电击持续时间短(P<0.01),电击后的潜伏期长[(70.55±19.76)s,(52.60±20.49)s,P<0.01];14-24JL组、24JL组与24C组比较差异有显著性:大鼠体质量增长慢[(446.12±22.34)g,(448.98±30.63)g,(487.18±26.70)g,P<0.01],跳台实验中遭受电击次数少(P<0.01),电击持续时间短(P<0.01),电击后的潜伏期长[(68.35±20.20)s,(61.15±22.14)s,(26.61±18.24)s,P<0.01].结论加味青麟丸具有提高学习记忆能力、延缓衰老的作用.
목적 관찰가미청린환대노령대서체질량화학습기억능력적영향.방법 선용Wistar대서120지,수궤분위6조:4월령공백대조조(4C조)、14월령공백대조조(14C조)、14월령가미청린환조(14JL조)、24월령공백대조조(24C조)、24월령가미청린환조(24JL조)화14～24월령가미청린환조(14～24JL조),매조각20지,자웅각반.각조균안실험설계요구분별위양후,비교각조대서적일반정황급체질량,채용도태실험검측각조대서학습、기억능력.결과 14JL조여14C조비교차이유현저성:대서체질량증장만[(315.28±20.35)g,(335.90±15.08)g,P<0.01],도태실험중조수전격차수소(P<0.01),전격지속시간단(P<0.01),전격후적잠복기장[(70.55±19.76)s,(52.60±20.49)s,P<0.01];14-24JL조、24JL조여24C조비교차이유현저성:대서체질량증장만[(446.12±22.34)g,(448.98±30.63)g,(487.18±26.70)g,P<0.01],도태실험중조수전격차수소(P<0.01),전격지속시간단(P<0.01),전격후적잠복기장[(68.35±20.20)s,(61.15±22.14)s,(26.61±18.24)s,P<0.01].결론 가미청린환구유제고학습기억능력、연완쇠로적작용.
Objective To observe the effects of Jiaweiqinglinwan on weight and the ability of learning and memory of aged rats.Methods 120 healthy Wistar rats are randomly divided into 6 groups after adaptation feed for one week,20 rats per group,that is 4-month control group(in brief 4C group),14-month control group(in brief 14C group),14-month JL group(in brief 14JL group),24-month control group(in brief 24C group),24-month JL group(in brief 24JL group)and 14-24-month JL group(in brief 14-24JL group),male and female half to half in every group.The ability of learning and memory by diving tower experimentation between different group rats with bed as the designe of the experiment.Results Compared rats in brief 14JL group with in brief 14C group,the weight creases slower(315.28±20.35,335.90±15.08,P<0.01),the times of sideration is fewer(P＜0.01),the duration of sideration is shorter(P＜0.01)and the time of diving tower is longer(70.55±19.76,52.60±20.49,P＜0.01).Compared mts in brief 14-24JL group and in brief 24JL group with in brief 24C group,the weight creases slower(446.12±22.34,448.98±30.63,487.18±26.70.P<0.01),the times of sideration is fewer(P＜0.01),the duration of sideration is shorter(P＜0.01)and the time of diving tower is longer(68.35±20.20,61.15±22.14,26.61±18.24,P＜0.01).Conclusion Jiaweiqinglinwan can improve the abilties of study and memory and postpone senescence.