CAJ | 학술논문

目的探讨慢性应激对小鼠创面愈合及移植皮片存活时间的影响.方法在C57BL/6J小鼠背部形成创面,术后将小鼠随机分到单纯创面组和慢性应激创面组,慢性应激创面组给予慢性刺激,观察两组创面愈合伤口情况;同时取BALB/C小鼠背部皮肤移植于C57BL/6J小鼠创面,术后将小鼠随机分到单纯移植组和慢性应激植皮组2个组,观察移植皮片存活情况.结果与单纯创面组相比,慢性应激创面组创面残余面积较大[第10天时分别为(20.33±0.38)%,(33.55±7.02)%],差异有显著性(P<0.01);而单纯皮片移植组与慢性应激皮片移植组皮片存活时间差异无显著性(P>0.05).结论慢性应激能够延缓创面愈合,而慢性应激对皮片移植影响则不明确,需要进一步研究.
목적 탐토만성응격대소서창면유합급이식피편존활시간적영향.방법 재C57BL/6J소서배부형성창면,술후장소서수궤분도단순창면조화만성응격창면조,만성응격창면조급여만성자격,관찰량조창면유합상구정황;동시취BALB/C소서배부피부이식우C57BL/6J소서창면,술후장소서수궤분도단순이식조화만성응격식피조2개조,관찰이식피편존활정황.결과 여단순창면조상비,만성응격창면조창면잔여면적교대[제10천시분별위(20.33±0.38)%,(33.55±7.02)%],차이유현저성(P<0.01);이단순피편이식조여만성응격피편이식조피편존활시간차이무현저성(P>0.05).결론 만성응격능구연완창면유합,이만성응격대피편이식영향칙불명학,수요진일보연구.
Objective To investigate the influence of chronic stress on skin wound healing and skin graft survival time in mice. Methods In the study on skin wound healing,a full-thickness dermal wound on the hack of the female C57 BL/6J mice was made, then the mice were randomly divided into simple wound group and wound plus chronic stress group. The chronic stress was given in the latter group. The wound healing conditions of two groups were observed. Meanwhile, the female C57BL/6J mice were grafted with skin donated from the female BALB/C mice,and randomly divided into,the simple skin graft group and the skin graft plus chronic stress group. The chronic stress was given in the latter group. The skin graft survival time of two groups were observed. Re-sults Compared with simple wound group, the healing speed of the wound plus chronic stress group was notably lower, and the difference was significant (P<0.01). However, no obvious distinction was observed on skin graft sur-vival time between the simple skin graft group and the skin graft plus chronic stress group(P>0.05). Conclusion Chronic stress may delay wound healing. But there is no certain conclusion that whether chronic stress impact on skin graft survival time. We need further investigation.