中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
8期
1059-1060
,共2页
二氯沙坦/氢氯噻嗪%氯沙坦%氢氯噻嗪%高血压%高尿酸血症
二氯沙坦/氫氯噻嗪%氯沙坦%氫氯噻嗪%高血壓%高尿痠血癥
이록사탄/경록새진%록사탄%경록새진%고혈압%고뇨산혈증
Hyzaar%Losartan%Hydrochlorothiazide%Hypertension%Hyperuricemia
目的 观察二氯沙坦/氢氯噻嗪治疗原发性高血压合并高尿酸血症的疗效与安全性.方法 选择178例原发性高血压合并高尿酸血症患者,随机分为对照组与观察组各89例,对照组每日服依那普利10 mg,氢氯噻嗪12.5 mg,观察组每日服二氯沙坦/氢氯噻嗪(每片含氯沙坦5 mg和氢氯塞嗪12.5 mg)1片,疗程均为8周.观察治疗前后血压、血尿酸水平的变化.结果 观察组与对照组降压总有效率分别为95.5%、93.3%,差异无统计学意义(P>0.05),观察组血尿酸水平较前明显降低(P<0.01),而对照组血尿酸变化无统计学意义.对照组干咳的发生率较高.结论 二氯沙坦/氢氯噻嗪治疗原发性高血压合并高尿酸血症患者,降压、降尿酸疗效佳且安全性好.
目的 觀察二氯沙坦/氫氯噻嗪治療原髮性高血壓閤併高尿痠血癥的療效與安全性.方法 選擇178例原髮性高血壓閤併高尿痠血癥患者,隨機分為對照組與觀察組各89例,對照組每日服依那普利10 mg,氫氯噻嗪12.5 mg,觀察組每日服二氯沙坦/氫氯噻嗪(每片含氯沙坦5 mg和氫氯塞嗪12.5 mg)1片,療程均為8週.觀察治療前後血壓、血尿痠水平的變化.結果 觀察組與對照組降壓總有效率分彆為95.5%、93.3%,差異無統計學意義(P>0.05),觀察組血尿痠水平較前明顯降低(P<0.01),而對照組血尿痠變化無統計學意義.對照組榦咳的髮生率較高.結論 二氯沙坦/氫氯噻嗪治療原髮性高血壓閤併高尿痠血癥患者,降壓、降尿痠療效佳且安全性好.
목적 관찰이록사탄/경록새진치료원발성고혈압합병고뇨산혈증적료효여안전성.방법 선택178례원발성고혈압합병고뇨산혈증환자,수궤분위대조조여관찰조각89례,대조조매일복의나보리10 mg,경록새진12.5 mg,관찰조매일복이록사탄/경록새진(매편함록사탄5 mg화경록새진12.5 mg)1편,료정균위8주.관찰치료전후혈압、혈뇨산수평적변화.결과 관찰조여대조조강압총유효솔분별위95.5%、93.3%,차이무통계학의의(P>0.05),관찰조혈뇨산수평교전명현강저(P<0.01),이대조조혈뇨산변화무통계학의의.대조조간해적발생솔교고.결론 이록사탄/경록새진치료원발성고혈압합병고뇨산혈증환자,강압、강뇨산료효가차안전성호.
Objective To observe the efficacy and safety of Hyzaar on hyperuricemia patients with essential hypertension.Methods 178 patients with essential hypertension and hyperuricemia were randomly divided into control group and observation group with each of 89 cases.Patients in the control group were treated with enalapril, 10 mg qd ,and hydrochlorothiazide, 12.5mg qd.Patients in the observation group were given 1 piece of Hyzaar tablet (5mg losartan and 12.5mg hydrochloride per tablet) per day for a course of 8 weeks.Blood pressure,serum uric acid level before and after the treatment were observed.Results Antihypertensive efficacy of the observation group and control group were 95.5% and 93.3% ,respectively( P > 0.05 ).Serum uric acid level of the observation group was significantly decreased than before treatment( P <0.01 ) ,while the serum uric acid of the control group showed no significant changes.The incidence of dry cough was higher in control group.Conclusion Hyzaar showed good efficacy in decreasing blood pressure and uric acid,and good safety in treating patients with primary hyperuricemia and hypertension.
