CAJ | 학술논문

目的测定布托啡诺抑制无痛人工流产术后宫缩痛的50％和95％有效剂量(ED50、ED95).方法选择26例要求行无痛人工流产术的早孕患者,术前5 min将布托啡诺按改良序贯法要求的剂量缓慢静脉推注,在麻醉深度监测下按200 mg/min速度给予普鲁泊福直至患者睫毛反射消失才开始手术,观察术后唤醒时、醒后10 min、醒后20 min患者宫缩痛情况,计算布托啡诺的ED50、ED95及相应的95％ CI.结果布托啡诺能有效抑制人工流产术后的宫缩痛；布托啡诺抑制人工流产术后宫缩痛的ED50和ED95分别是246 μg(95％ CI为201～281 μg)和324 μg(95％ CI为287 ～548 μg).结论在无痛人工流产术前5min,根据ED50、ED95给予适当剂量布托啡诺,可有效抑制患者术后宫缩痛,且能减少药物的不良反应.
목적 측정포탁배낙억제무통인공유산술후궁축통적50％화95％유효제량(ED50、ED95).방법 선택26례요구행무통인공유산술적조잉환자,술전5 min장포탁배낙안개량서관법요구적제량완만정맥추주,재마취심도감측하안200 mg/min속도급여보로박복직지환자첩모반사소실재개시수술,관찰술후환성시、성후10 min、성후20 min환자궁축통정황,계산포탁배낙적ED50、ED95급상응적95％ CI.결과 포탁배낙능유효억제인공유산술후적궁축통；포탁배낙억제인공유산술후궁축통적ED50화ED95분별시246 μg(95％ CI위201～281 μg)화324 μg(95％ CI위287 ～548 μg).결론 재무통인공유산술전5min,근거ED50、ED95급여괄당제량포탁배낙,가유효억제환자술후궁축통,차능감소약물적불량반응.
Objective To determine the dose of butorphanol at which 50％ and 95％ effective dose (ED50 and ED95) of patients inhibition uterine contraction pain on analgesic artificial abortion.Methods Twenty-six patients undergoing analgesic artificial abortion were sequentially given different doses butorphanol so that the ED50 and ED95 could be determined by up-and-down sequential test.Anesthetic depth was observed when giving propofol with 200 mg/min speed,uterine contraction pain at awaking immediately,10,20 min after awaleing.Data was analyzed by Probit regression analysis for calculating ED50 and ED95..Results Butorphanol could restrain uterine contraction pain on analgesic artificial abortion and the ED50 was 246 μg with the 95％ confidence interval of 201 μg to 281 μg,the ED95 was 324 μg with the 95％ confidence interval of 287 μg to 548 μg.Conclusion ED50 and ED95 value can be expected as a parameter to optimize analgesic artificial abortion.