CAJ | 학술논문

目的探讨乙醇脱氢酶(alcohol dehydrogenase,ADH)基因变异(ADH1B·1/2)与肥胖交互作用对早发冠心病的影响.方法采用病例对照研究方法,选择新诊断的冠心病患者为研究对象,男性≤55岁与女性≤65岁患冠心病为早发冠心病.以197例早发冠心病患者为病例组,205例迟发冠心病患者为对照组.体质指数(BMI)≥28 kg/m2为肥胖,运用聚合酶链式反应-限制性片段长度多态性检测ADH1B·1/2基因变异;采用多元Logistic回归调整潜在的混杂因素及估计比值比(OR).用相加模型分析ADH1B·1/2基因变异与肥胖问交互作?结果 ADH1B·1/2基因变异与肥胖对早发冠心病具有正交互作用,协同效应指数为2.07;交互效应超额相对危险度为1.20;归因交互效应百分比为36.1%.用多元Logistic回归调整性别、吸烟指数、饮酒指数、血清三酰甘油,总胆固醇、舒张压、收缩压、血糖后,ADH1B·1/2基因变异与肥胖之间对早发冠心病仍具有正交互作用.调整上述混杂因素后,协同效应指数为2.24;交互效应超额相对危险度为1.24;归因交互效应百分比为38.3%.结论 ADH1B·1/2基因变异与肥胖在早发冠心病的患病中存在正相加模型交互作用,使早发冠心病患病危险性增加约1.2倍;ADH1B·1/2基因变异与肥胖同时存在时,在早发冠心病患病危险性中约38.3%是由两者交互作用所导致.
목적 탐토을순탈경매(alcohol dehydrogenase,ADH)기인변이(ADH1B·1/2)여비반교호작용대조발관심병적영향.방법 채용병례대조연구방법,선택신진단적관심병환자위연구대상,남성≤55세여녀성≤65세환관심병위조발관심병.이197례조발관심병환자위병례조,205례지발관심병환자위대조조.체질지수(BMI)≥28 kg/m2위비반,운용취합매련식반응-한제성편단장도다태성검측ADH1B·1/2기인변이;채용다원Logistic회귀조정잠재적혼잡인소급고계비치비(OR).용상가모형분석ADH1B·1/2기인변이여비반문교호작?결과 ADH1B·1/2기인변이여비반대조발관심병구유정교호작용,협동효응지수위2.07;교호효응초액상대위험도위1.20;귀인교호효응백분비위36.1%.용다원Logistic회귀조정성별、흡연지수、음주지수、혈청삼선감유,총담고순、서장압、수축압、혈당후,ADH1B·1/2기인변이여비반지간대조발관심병잉구유정교호작용.조정상술혼잡인소후,협동효응지수위2.24;교호효응초액상대위험도위1.24;귀인교호효응백분비위38.3%.결론 ADH1B·1/2기인변이여비반재조발관심병적환병중존재정상가모형교호작용,사조발관심병환병위험성증가약1.2배;ADH1B·1/2기인변이여비반동시존재시,재조발관심병환병위험성중약38.3%시유량자교호작용소도치.
Objective To explore the effect of interaction between alcohol dehydrogenase 1B-1/2 (ADH1B·1/2) polymorphism and obesity on premature coronary heart disease (p-CHD).Methods Hospital-based case-control study was conducted.The newly diagnosed CHD patients were recruited as the subjects.One hundred and ninety-seven CHD patients diagnosed before 60 years old for males and 65 years old for females were assigned to the p-CHD case group with other 205 late onset CHD patients as the control group.Body mass index≥28 kg/m2 was defined as the obesity.Polymerase chain reaction-reatriction fragment length polymorphism was used to detect the ADH1B·1/2 polymorphism.Multivariate logistic regression model was performed to adjust the potential confounding factors and odds ratio estimation.Synergy index (S), relative excess risk due to interaction (RERI), and attributable proportion due to interaction (AP) were measured to assess the interaction as departure from additivity.Results There was a positive correlation between ADH1B ·1/2 polymorphism and obesity in patients with p-CAD.S was 2.07, RERI was 1.20, and AP was 36.1%.After adjusting sex, smoking index, alcohol drinking index, serum triglyceride, total cholesterol, diastolic blood pressure, systolic blood pressure and fasting plasma glucose by multiple logistic regression, there was also a positive correlation between ADH1B* 1/2 polymorphism and obesity.S was 2.24, RERI was 1.24, and AP was 38.3% after adjustment.Conclusions The interaction between ADH1B*1/2 polymorphism and obesity has a positive effect on the p-CAD in this studied population.