CAJ | 학술논문

对本院48例乳腺癌患者术后肿瘤组织的细胞信号传导通路的人类表皮生长因子受体2(HER2)、丝氨酸与苏氨酸激酶(Akt)、真核细胞始动因子4E结合蛋白1(4EBPl)、核糖体蛋白S6激酶1(p70S6K1)和核糖体S6行免疫组化染色检测.HER2阳性与阴性表达的肿瘤比较,Akt表达率更高(P<0.01).Akt表达的水平与其下游因子4EBPl、p70S6K1的表达呈正相关(P<0.01,P<0.05).4EBPl主要表达在低分化的肿瘤中(P<0.01),并与肿瘤大小(P<0.05)、淋巴结的转移(P<0.01)及局部复发相关(P<0.01).提示4EBPl与乳腺癌的肿瘤分级和预后密切相关.
대본원48례유선암환자술후종류조직적세포신호전도통로적인류표피생장인자수체2(HER2)、사안산여소안산격매(Akt)、진핵세포시동인자4E결합단백1(4EBPl)、핵당체단백S6격매1(p70S6K1)화핵당체S6행면역조화염색검측.HER2양성여음성표체적종류비교,Akt표체솔경고(P<0.01).Akt표체적수평여기하유인자4EBPl、p70S6K1적표체정정상관(P<0.01,P<0.05).4EBPl주요표체재저분화적종류중(P<0.01),병여종류대소(P<0.05)、림파결적전이(P<0.01)급국부복발상관(P<0.01).제시4EBPl여유선암적종류분급화예후밀절상관.
The expression of human epidermal growth factor receptor 2 (HER2), serine-threonine kinase (Akt), 4E-binding protein (4EBP1), phophorylated ribosomal protein S6 kinasel (p70S6Kl) and ribosomal protein S6 ( S6) were detected with immunohistochemistry in 48 cases of human breast cancer. Tumors high-expressing HER2 showed higher Akt expression as compared to tumors with negative HER2 (P < 0. 01). Levels of Akt were correlated with the downstream molecules 4EBP1 ( P < 0. 01) and p70S6K ( P < 0. 05 ). 4EBP1 was mainly expressed in poorly differentiated tumors (P <0. 01) and correlated with tumor size ( P < 0. 05) , lymph node metastasis ( P < 0. 01) and locoregional recurrences ( P < 0. 01). Results suggest that 4EBPl may be the main factor in PI-phosphoinositide-3-kinase (PI3K)-Akt-mammalian targot of rapanycin signal transduction pathways, which is associated with grade of malignancy and prognosis of breast cancer.