中华眼底病杂志
中華眼底病雜誌
중화안저병잡지
CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
2009年
6期
433-436
,共4页
视网膜电描记术/利用%视网膜炎%色素性/诊断
視網膜電描記術/利用%視網膜炎%色素性/診斷
시망막전묘기술/이용%시망막염%색소성/진단
Electroretinography/utilization%Retinitis pigmentosa/diagnosis
目的 观察视网膜色素变性(RP)患者视锥细胞和视杆细胞的多焦视网膜电图(mfERG)特征.评估感光细胞功能.方法 选取正常受试者8例8只眼进行视杆细胞mfERG检查.分析不同刺激光亮度对P1波振幅的影响;对19例RP患者38只眼分别进行视杆和视锥细胞mfERG检查.根据局部波形信噪比判断检出率,对视锥细胞mfERG不同类型间的平均视力、P1波振幅惭度进行比较和统计学分析.同时对比分析RP患者视杆和视锥细胞mfERG在各象限P1波振幅的变化.结果 采用0.04 cd/m~2蓝色低刺激光亮度可以稳定记录正常人视杆细胞mfERG反应.RP患者视锥和视杆细胞mfERG有效波形检出率分别为65.79%和10.51%.视锥mfERG I型P1波振幅密度高于Ⅱ型,差异有统计学意义(t=5.21,P=0.0000),平均视力差异无统汁学意义(t=1.15,P=0.612).I型振幅密度与logMAR视力呈负相关(r=-0.48,P=0.04).分别比较RP患者视锥和视杆mfERG局部波形特征发现,两者在各象限的P_1振幅密度在空间上有一定的对应性.结论 RP患者黄斑区视锥细胞的反应存在多样性,视锥细胞mfERG检出率高于视杆细胞,残存视锥和视杆细胞功能在空间上有一定的对应性.
目的 觀察視網膜色素變性(RP)患者視錐細胞和視桿細胞的多焦視網膜電圖(mfERG)特徵.評估感光細胞功能.方法 選取正常受試者8例8隻眼進行視桿細胞mfERG檢查.分析不同刺激光亮度對P1波振幅的影響;對19例RP患者38隻眼分彆進行視桿和視錐細胞mfERG檢查.根據跼部波形信譟比判斷檢齣率,對視錐細胞mfERG不同類型間的平均視力、P1波振幅慚度進行比較和統計學分析.同時對比分析RP患者視桿和視錐細胞mfERG在各象限P1波振幅的變化.結果 採用0.04 cd/m~2藍色低刺激光亮度可以穩定記錄正常人視桿細胞mfERG反應.RP患者視錐和視桿細胞mfERG有效波形檢齣率分彆為65.79%和10.51%.視錐mfERG I型P1波振幅密度高于Ⅱ型,差異有統計學意義(t=5.21,P=0.0000),平均視力差異無統汁學意義(t=1.15,P=0.612).I型振幅密度與logMAR視力呈負相關(r=-0.48,P=0.04).分彆比較RP患者視錐和視桿mfERG跼部波形特徵髮現,兩者在各象限的P_1振幅密度在空間上有一定的對應性.結論 RP患者黃斑區視錐細胞的反應存在多樣性,視錐細胞mfERG檢齣率高于視桿細胞,殘存視錐和視桿細胞功能在空間上有一定的對應性.
목적 관찰시망막색소변성(RP)환자시추세포화시간세포적다초시망막전도(mfERG)특정.평고감광세포공능.방법 선취정상수시자8례8지안진행시간세포mfERG검사.분석불동자격광량도대P1파진폭적영향;대19례RP환자38지안분별진행시간화시추세포mfERG검사.근거국부파형신조비판단검출솔,대시추세포mfERG불동류형간적평균시력、P1파진폭참도진행비교화통계학분석.동시대비분석RP환자시간화시추세포mfERG재각상한P1파진폭적변화.결과 채용0.04 cd/m~2람색저자격광량도가이은정기록정상인시간세포mfERG반응.RP환자시추화시간세포mfERG유효파형검출솔분별위65.79%화10.51%.시추mfERG I형P1파진폭밀도고우Ⅱ형,차이유통계학의의(t=5.21,P=0.0000),평균시력차이무통즙학의의(t=1.15,P=0.612).I형진폭밀도여logMAR시력정부상관(r=-0.48,P=0.04).분별비교RP환자시추화시간mfERG국부파형특정발현,량자재각상한적P_1진폭밀도재공간상유일정적대응성.결론 RP환자황반구시추세포적반응존재다양성,시추세포mfERG검출솔고우시간세포,잔존시추화시간세포공능재공간상유일정적대응성.
Objective To observe the mutifocal electroretinogram (mfERG) characteristics of rod and cone cells in patients with retinitis pigmentosa (RP) and to evaluate the function of photosensory cell.Methods The mfERG recording technique for rod cell in eight normal subjects (eight eyes) were established and the influence of different brightness lightstimulus in P1 wave amplitude were analyzed.The cone and rod cells mfERG of 38 eyes in 19 patients were recorded and then calculated positive ratio from local signal-noise ratio.The average visual acuity and P1 wave amplitude density of cone mtERG in different types were compared and statistically analyzed.Meanwhile,the changes in P1 wave amplitude of cone and rod mfERG in four quadrants also compared and analyzed.Results Rod cell mfERG in normal subjects can be recorded stably by using blue flashes with low light intensity as 0.04 cd/m~2.In patients with RP,the cone and rod cells mfERG can he detectd 65.790./00 and 10.51% respectively.P1 wave amplitude density in type I of cone cell mfERG was significantly higher than that in type Ⅱ (t=5.21,P=0.000).There were no differences in average visual acuity (t=1.15,P=0.612).P1 wave amplitude density in type Ⅰ was negatively related to IogMAR visual acuity (r=-0.48,P=0.04 ).The comparison of rod and cone cells mfERG in local wave characteristics showed that P_1 wave amplitude densities had spatial relationship in each area.Conclusions The results suggested highly variable central responses in cone cell in RP patients,higher positive recorded ratio in cone cell than rod cell and spatial correspondence between the function of reserved cone and rod cells.
