CAJ | 학술논문

目的探讨系统性红斑狼疮(SLE)并发股骨头坏死(ONFH)的临床特点和危险因素.方法对我院确诊的376例SLE患者的临床及随访资料进行回顾性分析,以了解SLE合并ONFH的患病情况和危险因素.结果376例SLE股骨头坏死的发病率为7.18%(27/376),其中双侧16例(59.26%),单侧11例(40.74%);其危险因素包括口腔溃疡、雷诺氏现象、血管炎、TC、TG、累积激素用量及是否行激素冲击;在随访分析中,大剂量激素冲击治疗组患者股骨头缺血坏死终点事件的发生率显著高于非大剂量激素冲击治疗组,分别为12.50%比5.92%(P<0.05).结论 SLE患者发生股骨头坏死的危险性相对较高,血管炎、口腔溃疡、雷诺氏现象、高脂血症、激素治疗是其危险因素,尤其是大剂量糖皮质激素冲击治疗.
목적 탐토계통성홍반랑창(SLE)병발고골두배사(ONFH)적림상특점화위험인소.방법 대아원학진적376례SLE환자적림상급수방자료진행회고성분석,이료해SLE합병ONFH적환병정황화위험인소.결과376례SLE고골두배사적발병솔위7.18%(27/376),기중쌍측16례(59.26%),단측11례(40.74%);기위험인소포괄구강궤양、뢰낙씨현상、혈관염、TC、TG、루적격소용량급시부행격소충격;재수방분석중,대제량격소충격치료조환자고골두결혈배사종점사건적발생솔현저고우비대제량격소충격치료조,분별위12.50%비5.92%(P<0.05).결론 SLE환자발생고골두배사적위험성상대교고,혈관염、구강궤양、뢰낙씨현상、고지혈증、격소치료시기위험인소,우기시대제량당피질격소충격치료.
Objective To investigate the risk factor of osteonecrosis of the femoral head (ONFH)in patients with systemic lupus erythematosus (SLE).Methods 376 patients with SLE in our hospital were enrolled in the present study.The retrospective analysis was made to investigate the risk factor of ONFH on the pathological and follow-up data.Results The incidence of ONFH in 376 SLE patients was 7.18%.Oral ulcer,Renault's phenomenon,vasculitis,osteoporosis,TC,TG,accumulated dosage of hormone and hormone intensive therapy were the risk factors of ONFH.Conclusion The incidence of ONFH in patients with SLE is relatively high,and the risk factors include Renault' s phenomenon,vasculitis,osteoporosis,TC,TG and usage of immunosuppresive treatment,especially the hormone intensive therapy with large doses.