CAJ | 학술논문

目的探讨两种超声造影剂不同剂量和机械指数(MI)条件下的显像效果.方法分别对8只新西兰大白兔多次团注超声造影剂SonoVue(0.06 ml/kg、0.12 ml/kg)及Sonazoid(0.045 ml/kg、0.09ml/kg),SonoVue组每个剂量水平分别设置7个MI值(0.10～0.55),Sonazoid组每个剂量水平分别设置5个MI值(0.19～0.98).应用视频密度分析软件对显像过程做定量分析,并比较其峰值强度(PI).结果在相同发射频率(7 MHz)条件下:SonoVue组不同剂量组PI值均于MI=0.15时达最大值(P<0.05);相同MI下,高剂量组PI值较大.Sonazoid组不同剂量组PI值均于MI=0.40时达最大值(P<0.05);相同MI下,高剂量组PI值较大.结论 SonoVue与Sonazoid显像条件不同,临床使用中需兼顾造影剂剂量、MI值及频率的影响.
목적 탐토량충초성조영제불동제량화궤계지수(MI)조건하적현상효과.방법 분별대8지신서란대백토다차단주초성조영제SonoVue(0.06 ml/kg、0.12 ml/kg)급Sonazoid(0.045 ml/kg、0.09ml/kg),SonoVue조매개제량수평분별설치7개MI치(0.10～0.55),Sonazoid조매개제량수평분별설치5개MI치(0.19～0.98).응용시빈밀도분석연건대현상과정주정량분석,병비교기봉치강도(PI).결과 재상동발사빈솔(7 MHz)조건하:SonoVue조불동제량조PI치균우MI=0.15시체최대치(P<0.05);상동MI하,고제량조PI치교대.Sonazoid조불동제량조PI치균우MI=0.40시체최대치(P<0.05);상동MI하,고제량조PI치교대.결론 SonoVue여Sonazoid현상조건불동,림상사용중수겸고조영제제량、MI치급빈솔적영향.
Objective To compare the contrast enhancement effects of SonoVue and Sonazoid in rabbit liver at ultrasonic frequency of 7 MHz using various mechanical index(MI) and dosage. Methods Eight rabbits were bolus injected with different contrast agents:for SonoVue(0. 06 ml/kg,0. 12 ml/kg) ,MI ranging 0. 10 - 0. 55; while Sonazoid (0. 045 ml/kg, 0. 09 ml/kg) , MI ranging 0. 19 - 0. 98. Quantitative analysis of ultrasonography was done using video-intensity analysis system, and peak intensity (PI) was compared. Results With the same frequency, in SonoVue group, for both dosage groups, PI reached maximum at MI = 0. 15 ( P <0. 05) ; with the same MI, PI of the high dosage group was higher ( P < 0. 05). In Sonazoid group,for both dosage groups,PI reached maximum at MI = 0. 40( P <0. 05) ; with the same MI,PI of the high dose group was higher ( P <0. 05). Conclusions The optimistic ultrasonographic conditions provided to SonoVue and Sonazoid are different. Dosage of contrast agents, MI and frequency need to be concerned.