CAJ | 학술논문

大肠癌是最常见的癌症之一,尽管转移患者采取化疗和手术联合治疗后生存率已经有所提高,但是长期存活的患者仍然少之又少.循环肿瘤细胞(CTC)检测是最近兴起的技术,其临床意义已被讨论了将近一个多世纪.科技的日新月异使CTC的检测变得更加可行,最近的研究都相似地揭示CTC可以预测结直肠癌转移患者的临床结局.此篇综述将讨论CTC的检测方法、临床意义与结直肠癌转移患者(mCRC)临床预后的关系,及未来指导mCRC患者个体化治疗所面临的挑战.
대장암시최상견적암증지일,진관전이환자채취화료화수술연합치료후생존솔이경유소제고,단시장기존활적환자잉연소지우소.순배종류세포(CTC)검측시최근흥기적기술,기림상의의이피토론료장근일개다세기.과기적일신월이사CTC적검측변득경가가행,최근적연구도상사지게시CTC가이예측결직장암전이환자적림상결국.차편종술장토론CTC적검측방법、림상의의여결직장암전이환자(mCRC)림상예후적관계,급미래지도mCRC환자개체화치료소면림적도전.
Colorectal cancer is one of the most common cancer.Despite the survival rate of patients with metastatic disease has been raised due to the combination therapy of chemotherapy and opetation,few longterm survivors exist.The detection of circulating tumor cells (CTC) is an evolving technology whose significance has been discussed for more than a century.The advence of modem technology has allowed for more reliable detection of CTCs,and recent studies have provided compelling evidence that CTCs can predict clinical outcome in metastatic colorectal cancer (mCRC).In this review,we will discuss the evidence for CTC significance,with particular focus on detection methods,novel markers,and clinical outcomes in CRC,and future challenges in testing them as a means to individualize the therapy of mCRC patients.