国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2010年
4期
427-429
,共3页
肥胖%黑皮素4%受体%基因突变
肥胖%黑皮素4%受體%基因突變
비반%흑피소4%수체%기인돌변
Obesity%Melanocortin 4 receptor%Gene mutation
黑皮素4受体 (melanocortin 4 receptor,MC4R)基因突变是引起人类肥胖最常见的原因.MC4R是5种已被发现的黑皮素受体之一,位于18 号染色体,由单一外显子构成. 研究证实MC4R基因与体质量调节密切相关,其突变能导致青少年严重肥胖,与遗传性肥胖病密切相关.
黑皮素4受體 (melanocortin 4 receptor,MC4R)基因突變是引起人類肥胖最常見的原因.MC4R是5種已被髮現的黑皮素受體之一,位于18 號染色體,由單一外顯子構成. 研究證實MC4R基因與體質量調節密切相關,其突變能導緻青少年嚴重肥胖,與遺傳性肥胖病密切相關.
흑피소4수체 (melanocortin 4 receptor,MC4R)기인돌변시인기인류비반최상견적원인.MC4R시5충이피발현적흑피소수체지일,위우18 호염색체,유단일외현자구성. 연구증실MC4R기인여체질량조절밀절상관,기돌변능도치청소년엄중비반,여유전성비반병밀절상관.
Mutations in the melanocortin 4 receptor (MC4R) represent the most common known cause of monogenic human obesity.MC4R is a family of the five melanocortin receptors.It is an exon lying on chromosome 18.Studies have proved that there is a closed relationship between MC4R and weight regulation.MC4R mutation can result in severer adolescent obesity.
