CAJ | 학술논문

目的评价肿瘤坏死因子-α(TNF-α)238、转化生长因子-β(TGF-β)(509和869)位点基因多态性与尘肺易感性.方法检索Elsevier、PubMed、Wiley Online Library、EMCC、Web of Science外文数据库和中国期刊全文数据库、维普数据库、万方数据库、中国生物医学文献数据库中文数据库及Cochrane图书馆文献(1988年1月至2011年8月),收集上述基因位点与尘肺易感性的病例对照研究或队列研究.共检索到28篇相关文献,20篇纳入研究.应用RevMan4.2软件对各研究结果进行异质性检验和效应值合并.结果 20篇纳入研究中有TNF-α238位点文献10篇(涉及2232例尘肺患者和1985例对照人群),TGF-β509位点文献4篇(涉及693例尘肺患者和663例对照人群),TGF-β869位点文献6篇(涉及1450例尘肺患者和1101例对照人群).Meta分析结果表明,TNF-α238位点基因多态性与尘肺易感性相关:携带GA+AA基因型的个体患尘肺的风险性高于GG基因型个体(OR=1.53,95％CI:1.25～1.88);携带A等位基因的个体患尘肺的风险性高于G等位基因个体(OR=1.64,95％CI:1.17～2.30);分层分析显示,矽肺人群、亚洲人群和接尘工人中携带GA+AA基因型和A等位基因患尘肺的风险性增高(OR=2.14,95％ CI:1.20～3.82;OR=2.16,95％CI:1.20～3.88;OR=1.78,95％ CI:1.01～3.11;OR=1.83,95％CI:1.04～3.22;OR=1.80,95％CI:1.21～2.66;OR=1.50,95％CI:1.23～1.83).TGF-β(509和869)位点基因多态性与尘肺易感性的相关性无统计学意义:携带CT+TT基因型个体患尘肺的风险性不高于CC基因型(OR=1.56,95％CI:0.81～3.01;OR=0.96,95％CI:0.79～1.18),携带T等位基因的个体患尘肺的风险性不高于C等位基因(OR=1.35,95％CI:0.86～2.13;OR=1.02,95％CI:0.91～1.15).结论 TNF-α238 位点基因多态性与尘肺易感性有关,TGF-β(509和869)位点基因多态性与尘肺易感性无关.
목적 평개종류배사인자-α(TNF-α)238、전화생장인자-β(TGF-β)(509화869)위점기인다태성여진폐역감성.방법 검색Elsevier、PubMed、Wiley Online Library、EMCC、Web of Science외문수거고화중국기간전문수거고、유보수거고、만방수거고、중국생물의학문헌수거고중문수거고급Cochrane도서관문헌(1988년1월지2011년8월),수집상술기인위점여진폐역감성적병례대조연구혹대렬연구.공검색도28편상관문헌,20편납입연구.응용RevMan4.2연건대각연구결과진행이질성검험화효응치합병.결과 20편납입연구중유TNF-α238위점문헌10편(섭급2232례진폐환자화1985례대조인군),TGF-β509위점문헌4편(섭급693례진폐환자화663례대조인군),TGF-β869위점문헌6편(섭급1450례진폐환자화1101례대조인군).Meta분석결과표명,TNF-α238위점기인다태성여진폐역감성상관:휴대GA+AA기인형적개체환진폐적풍험성고우GG기인형개체(OR=1.53,95％CI:1.25～1.88);휴대A등위기인적개체환진폐적풍험성고우G등위기인개체(OR=1.64,95％CI:1.17～2.30);분층분석현시,석폐인군、아주인군화접진공인중휴대GA+AA기인형화A등위기인환진폐적풍험성증고(OR=2.14,95％ CI:1.20～3.82;OR=2.16,95％CI:1.20～3.88;OR=1.78,95％ CI:1.01～3.11;OR=1.83,95％CI:1.04～3.22;OR=1.80,95％CI:1.21～2.66;OR=1.50,95％CI:1.23～1.83).TGF-β(509화869)위점기인다태성여진폐역감성적상관성무통계학의의:휴대CT+TT기인형개체환진폐적풍험성불고우CC기인형(OR=1.56,95％CI:0.81～3.01;OR=0.96,95％CI:0.79～1.18),휴대T등위기인적개체환진폐적풍험성불고우C등위기인(OR=1.35,95％CI:0.86～2.13;OR=1.02,95％CI:0.91～1.15).결론 TNF-α238 위점기인다태성여진폐역감성유관,TGF-β(509화869)위점기인다태성여진폐역감성무관.
Objective To evaluate the relationship between tumor necrosis factor-alpha-238,transforming growth factor beta (509 and 869) gene polymorphisms and pneumoconiosis susceptibility.Methods We searched published full-text from foreign language databases including Elsevier,PubMed,Wiley Online Library,EMCC,Web of Science,chinese databases containing CNKI,VIP,Wanfang,CBM and Cochrane library to collect case-control or cohort study on gene gene polymorphisms said above with pneumoconiosis susceptibility from the year January1988 to August 2011.28 relevant articles were selected and 20 of them met the criteria.The correlated index was extracted for aggregate analysis in RevMan 4.2.Results Among the 20 studies,10 articles on TNF-α238 polymorphism (including 2232 pneumoconiosis cases and 1985 control subjects),4 articles on TGF-β509 polymorphism (including 693 pneumoconiosis cases and 663 control subjects),and 6 articles on TGF-3869 polymorphism (including 1450 pneumoconiosis cases and 1101 control subjects) were included in the current study.Meta-analysis results showed that there was a significant association between TNF-α238 polymorphism and pneumoconiosis:the population with GA and AA genotypes of TNF-α238 had higher risks to pneumoconiosis (OR=1.53,95％CI:1.25～1.88) comparing to GG genotype,and the population with A allele had higher risks to pneumoconiosis comparing to allele G (OR=1.64,95％CI:1.17 ～2.30).The stratified analysis showed that the people with GA and AA genotypes and A allele who were silicosis,Asian or exposed to dust had higher risks to pneumoconiosis (OR=2.14,95％CI:1.20～3.82; OR=2.16,95％CI:1.20～3.88; OR=1.78,95％CI:1.01～3.11; OR=1.83,95％CI:1.04～3.22; OR=1.80,95％CI:1.21～2.66;OR=1.50,95％CI:1.23～1.83).No significant association was found between TGF-β (509 and 869) gene polymorphisms with pneumoconiosis:In contrast to the CC genotype,the population who had CT and TT genotypes had no higher risks to pneumoconiosis( OR=1.56,95％CI:0.81～3.01; OR=0.96,95％CI:0.79～1.18 ); The population who had T allele had no higher risks to pneumoconiosis in contrast to the C allele (OR=1.35,95％CI:0.86～2.13; OR=1.02,95％CI:0.91～1.15).Conclusion Significant association was found between TNF-α238 gene polymorphism and pneumoconiosis; and TGF-β (509 and 869) were not.