乙型肝炎患者血清HBV DNA和e系统相关性的研究
을형간염환자혈청HBV DNA화e계통상관성적연구
STUDY ON RELATIONSHIP BETWEEN HBV DNA AND e SYSTEM IN HEPATITIS B PATIENTS
  • 万方数据
    中华传染病杂志 중화전염병잡지
    CHINESE JOURNAL OF INFECTIOUS DISEASES
    1988年 1期 14-17 ,共4页

    闵贤%黎海苓%陆北川%韩亚萍%贾辅忠

    민현%려해령%륙북천%한아평%가보충

    乙型肝炎%HBVDNA%斑点杂交试验 乙型肝炎%HBVDNA%斑點雜交試驗
    을형간염%HBVDNA%반점잡교시험
    Hepatitis B HBV DNA spot hybridization test
    本文对172例乙型肝炎患者应用斑点杂交方法测定血清HRVDNI.在HBeAg阳性患者中血清HBVDNA检出率为90.10%;而在HBsAg阳性,但HBeAg和抗HBe均为阴性或抗HBe阳性患者中血清HBVDNI检出率分别为23.52%和28.13%以上结果提示HBeAg和血清HBVDNA密切相关,且反映了病毒的活动性复制,而抗HBc阳性并不意味着病毒复制已停止和不再有传染性.根据我们的资料还可看出HBeAg和血清HBVDNA同时阳性者多见于无症状HBsAg携带者、急性肝炎和慢性迁延性肝炎患者.与此相反,抗-HBe和血清HBVDNA同时阳性者则多见于慢性活动性肝炎和肝硬化患者.由此可见,HBeAg和血清HBVDNA的不一致性与肝脏病变的进展程度有关.
    본문대172례을형간염환자응용반점잡교방법측정혈청HRVDNI.재HBeAg양성환자중혈청HBVDNA검출솔위90.10%;이재HBsAg양성,단HBeAg화항HBe균위음성혹항HBe양성환자중혈청HBVDNI검출솔분별위23.52%화28.13%이상결과제시HBeAg화혈청HBVDNA밀절상관,차반영료병독적활동성복제,이항HBc양성병불의미착병독복제이정지화불재유전염성.근거아문적자료환가간출HBeAg화혈청HBVDNA동시양성자다견우무증상HBsAg휴대자、급성간염화만성천연성간염환자.여차상반,항-HBe화혈청HBVDNA동시양성자칙다견우만성활동성간염화간경화환자.유차가견,HBeAg화혈청HBVDNA적불일치성여간장병변적진전정도유관.
    We have assessed the presence of HBV DNA in serum samples from 172 patients with HBsAg-positive hepatitis B by hybridiization test with cloned HBV DNA probe.It was found that the positive rates of serum HBV DNA were 90.10%,28.13% and 23.52% in HBeAg positive,anti-I-tBe positire and e system negative patients respectively.The results indicate that there is a close correlation between serum HBV DNA and e system.The serum HBV DNA is more sensitive than e system in reflecting the replication of HBV.On the other hand,the data showed that the model of both positive HBV DNA and HBeAg was often seen in HBsAg carrier,acute hepatitis and CPH,while the model of both positive HBV DNA and anti-HBe often seen in cirrhosis and GAH.It seems tbat there are some relationships between the aforementioned different models an d various degrees of severity of hepatitis.
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