国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2011年
4期
494-496
,共3页
过氧化物酶Ⅱ%过氧化氢%缺血/再灌注损伤
過氧化物酶Ⅱ%過氧化氫%缺血/再灌註損傷
과양화물매Ⅱ%과양화경%결혈/재관주손상
Peroxiredoxin Ⅱ%H202%Ischemia/reperfusion injury
背景过氧化物酶(peroxiredoxins，Prxs)在氧化应激反应中具有重要的保护作用。近年来研究发现，过氧化物酶Ⅱ(PrxⅡ)在心肌缺血/再灌注中变化显著，上调PrxⅡ表达对氧化应激损伤具有显著的保护作用，其作用机制有待澄清。目的总结PrxⅡ在氧化应激损伤中保护作用的调控机制，为改善缺血/再灌注损伤（ischemia/reperfusion injury，I/RI）的疗效提供新的思路。内容就PrxⅡ在心肌保护中的作用及研究进展做简要的综述。 趋向PrxⅡ可能会成为氧化应激损伤中保护心脏的潜在靶点。
揹景過氧化物酶(peroxiredoxins，Prxs)在氧化應激反應中具有重要的保護作用。近年來研究髮現，過氧化物酶Ⅱ(PrxⅡ)在心肌缺血/再灌註中變化顯著，上調PrxⅡ錶達對氧化應激損傷具有顯著的保護作用，其作用機製有待澄清。目的總結PrxⅡ在氧化應激損傷中保護作用的調控機製，為改善缺血/再灌註損傷（ischemia/reperfusion injury，I/RI）的療效提供新的思路。內容就PrxⅡ在心肌保護中的作用及研究進展做簡要的綜述。 趨嚮PrxⅡ可能會成為氧化應激損傷中保護心髒的潛在靶點。
배경과양화물매(peroxiredoxins，Prxs)재양화응격반응중구유중요적보호작용。근년래연구발현，과양화물매Ⅱ(PrxⅡ)재심기결혈/재관주중변화현저，상조PrxⅡ표체대양화응격손상구유현저적보호작용，기작용궤제유대징청。목적총결PrxⅡ재양화응격손상중보호작용적조공궤제，위개선결혈/재관주손상（ischemia/reperfusion injury，I/RI）적료효제공신적사로。내용취PrxⅡ재심기보호중적작용급연구진전주간요적종술。 추향PrxⅡ가능회성위양화응격손상중보호심장적잠재파점。
Background Peroxiredoxins play crucial roles in protecting heart from oxidative stress-induced injury. Several lines of evidence suggest that expression level of peroxiredoxin Ⅱ (Prx Ⅱ ) was sharply changed in ischemia/reperfusion myocardium and the overexpression of Prx Ⅱ significantly protected from H202-induced apoptosis and necrosis. And the underlying mechanisms were worth identifying. Objective To summarize the regulatory mechanisms on protective effect of Prx Ⅱ in oxidative stress-induced injury-may provide a promising way for cardiac protection from ischemia and reperfusion injury. Content To discuss the mechanisms underlying the protective role of Prx Ⅱ in oxidative stress-induced injury. Trend Prx Ⅱ may be a potential target for treating cardiac oxidative stress-induced injury.
