CAJ | 학술논문

大多数蒽环类抗生素中的糖基部分都是3-氨基-2,3,6-三脱氧己糖,糖基部分对药物分子的活性起着至关重要的作用.多样性脱氧己糖的合成对分析柔红霉素及其结构类似物的构效关系意义重大.介绍了一种从鼠李醛出发合成两种3-氨基-2,3,6-三脱氧己糖的新方法.
대다수은배류항생소중적당기부분도시3-안기-2,3,6-삼탈양기당,당기부분대약물분자적활성기착지관중요적작용.다양성탈양기당적합성대분석유홍매소급기결구유사물적구효관계의의중대.개소료일충종서리철출발합성량충3-안기-2,3,6-삼탈양기당적신방법.
3-azido-2,3,6-trideoxy-L-hexoses exited in the molecule of anthracyclines play vital roles in the biologic activity of these drugs.The synthesis of multiform deoxy-hexoses have large significance of structure-activity relationships of the anthracyclines and their structural analogs.A divergent strategy to synthesise daunosamine and 3-epi-daunosamine from L-di-O-acetylrhamnal have been reported.