泰山学院学报
泰山學院學報
태산학원학보
JOURNAL OF TAISHAN UNIVERSITY
2011年
3期
98-101
,共4页
泰山四叶参%乌拉坦%肺癌%预防和抑制作用%机制
泰山四葉參%烏拉坦%肺癌%預防和抑製作用%機製
태산사협삼%오랍탄%폐암%예방화억제작용%궤제
Radix Codonopsis Lanceolata from Mount Taishan%urethan%lung cancer%prevention and inhibition%mechanism
研究泰山四叶参对乌拉坦诱导的小鼠肺癌的作用及其可能的作用机理.用乌拉坦诱导小鼠建立肺癌模型,随机分组在不同时间饲喂泰山四叶参粗多糖,观察小鼠生存状况,记录其体重变化、内脏(胸腺、脾、肝脏、肺、心脏)指数和存活时间,检测巨噬细胞吞噬功能和血清、肝脏、肺中SOD活性.结果发现泰山四叶参能改善乌拉坦所致肺癌小鼠的生存质量,提高了小鼠的胸腺指数和脾脏指数,增强肝脏中SOD活性,显著延长了其存活时间.因此,泰山四叶参对乌拉坦诱导的小鼠肺癌有一定的预防和抑制作用,主要机制可能与其免疫调节、抗氧化作用有关.
研究泰山四葉參對烏拉坦誘導的小鼠肺癌的作用及其可能的作用機理.用烏拉坦誘導小鼠建立肺癌模型,隨機分組在不同時間飼餵泰山四葉參粗多糖,觀察小鼠生存狀況,記錄其體重變化、內髒(胸腺、脾、肝髒、肺、心髒)指數和存活時間,檢測巨噬細胞吞噬功能和血清、肝髒、肺中SOD活性.結果髮現泰山四葉參能改善烏拉坦所緻肺癌小鼠的生存質量,提高瞭小鼠的胸腺指數和脾髒指數,增彊肝髒中SOD活性,顯著延長瞭其存活時間.因此,泰山四葉參對烏拉坦誘導的小鼠肺癌有一定的預防和抑製作用,主要機製可能與其免疫調節、抗氧化作用有關.
연구태산사협삼대오랍탄유도적소서폐암적작용급기가능적작용궤리.용오랍탄유도소서건립폐암모형,수궤분조재불동시간사위태산사협삼조다당,관찰소서생존상황,기록기체중변화、내장(흉선、비、간장、폐、심장)지수화존활시간,검측거서세포탄서공능화혈청、간장、폐중SOD활성.결과발현태산사협삼능개선오랍탄소치폐암소서적생존질량,제고료소서적흉선지수화비장지수,증강간장중SOD활성,현저연장료기존활시간.인차,태산사협삼대오랍탄유도적소서폐암유일정적예방화억제작용,주요궤제가능여기면역조절、항양화작용유관.
Objective: To study the effect of Radix Codonopsis Lanceolata from Mount Taishan on urethan -induced lung cancer in mice and its possible mechanism. Methods: Mice were randomly divided into six groups when the mice were carcinogenic with urethan. We observed the growth of mice, took the record of its body weight, viscera index of thymus, spleen, liver, lung, heart, and detected its phagocytic function of mac- rophage and SOD activity in serum, plasma, liver and lung. Results: Radix Codonopsis Laneeolata from Mount Taishan can improve the quality of life of the mice with urethan - induced lung cancer and prolong its survival time significantly. It can also improve the thymus index and spleen index and increase the SOD activity in liver. Conclusion: Radix Codonopsis Lanceolata from Mount Taishan can prevent and inhibit the urethan - induced lung cancer in mice. The primary mechanism may be related to its activity of immune regulation and anti - oxidation.