生物技术进展
生物技術進展
생물기술진전
2011年
2期
122-129
,共8页
人表皮细胞生长因子%信号通路%活性%制备
人錶皮細胞生長因子%信號通路%活性%製備
인표피세포생장인자%신호통로%활성%제비
human epidermal growth factor (hEGF)%signal pathways%activities%preparation
表皮细胞生长因子是人体内一种重要自分泌/旁分泌的生长因子。人表皮细胞生长因子及其受体调控细胞增殖、分化、迁移、生存等与细胞命运密切相关的过程,在细胞发育、伤口愈合、器官发生中发挥重要作用。本文将对人表皮细胞生长因子的合成、分泌、生化特性、分子结构、家族、受体、信号通路、生物学活性、生理功能、应用及制备方法等方面进行综述。
錶皮細胞生長因子是人體內一種重要自分泌/徬分泌的生長因子。人錶皮細胞生長因子及其受體調控細胞增殖、分化、遷移、生存等與細胞命運密切相關的過程,在細胞髮育、傷口愈閤、器官髮生中髮揮重要作用。本文將對人錶皮細胞生長因子的閤成、分泌、生化特性、分子結構、傢族、受體、信號通路、生物學活性、生理功能、應用及製備方法等方麵進行綜述。
표피세포생장인자시인체내일충중요자분비/방분비적생장인자。인표피세포생장인자급기수체조공세포증식、분화、천이、생존등여세포명운밀절상관적과정,재세포발육、상구유합、기관발생중발휘중요작용。본문장대인표피세포생장인자적합성、분비、생화특성、분자결구、가족、수체、신호통로、생물학활성、생리공능、응용급제비방법등방면진행종술。
Human epidermal growth factor (hEGF) is an important autocrine/paracrine factor in human body. hEGF and its receptor regulate key processes of cell biology, including proliferation, differentiation, migration and survival of cells. hEGF plays an important role in cell develepmnet, wound healing and organogenesis. This paper summarizes the hEGF synthesis, secretion, biochemical character, molecular structure, family, receptor, signal pathways, bioactivity, physiological function, applications, and the methods of production.