化学分析计量
化學分析計量
화학분석계량
CHEMICAL ANALYSIS AND METERAGE
2010年
3期
58-60
,共3页
四氟硼酸根%对甲基苯磺酸根%硫酸根%1,4-丁二磺酸根%离子色谱法
四氟硼痠根%對甲基苯磺痠根%硫痠根%1,4-丁二磺痠根%離子色譜法
사불붕산근%대갑기분광산근%류산근%1,4-정이광산근%리자색보법
tetrafluoroborate,p-toluene sulphonic acid,sulfate radical,1,4-Butanedisulfonic acid,ion chromatography
采用离子色谱法同时测定合成药物中存在的四氟硼酸根、对甲基苯磺酸根、硫酸根、1，4-丁二磺酸根4种离子。对淋洗液及淋洗流速等色谱条件进行了优化，4种离子的分离度好，检测灵敏度高。被测离子的浓度在一定范围内与色谱峰面积呈良好的线性关系，相关系数r〉0．999。4种离子测定结果的相对标准偏差小于1％（n=9），加标回收率为98．2％-110．0％。
採用離子色譜法同時測定閤成藥物中存在的四氟硼痠根、對甲基苯磺痠根、硫痠根、1，4-丁二磺痠根4種離子。對淋洗液及淋洗流速等色譜條件進行瞭優化，4種離子的分離度好，檢測靈敏度高。被測離子的濃度在一定範圍內與色譜峰麵積呈良好的線性關繫，相關繫數r〉0．999。4種離子測定結果的相對標準偏差小于1％（n=9），加標迴收率為98．2％-110．0％。
채용리자색보법동시측정합성약물중존재적사불붕산근、대갑기분광산근、류산근、1，4-정이광산근4충리자。대림세액급림세류속등색보조건진행료우화，4충리자적분리도호，검측령민도고。피측리자적농도재일정범위내여색보봉면적정량호적선성관계，상관계수r〉0．999。4충리자측정결과적상대표준편차소우1％（n=9），가표회수솔위98．2％-110．0％。
A new method of simultaneous separating and determining tetrafluoroborate, p-toluene sulphonic acid, sulfate radical and 1,4-Butanedisulfonie acid by ion chromatography was established. Chromatography conditions such as eluant and its flow rate were optimized. Four ions were well separated with high sensitivity in the optimized experiment conditions. Concentration of each inon was linear with its peak area, and linear correlation coefficient was more than 0.999. The RSD of detection results was less than 1% （ n = 9） , and the recoveries were 98.2% - 110.0%.
