CAJ | 학술논문

目的　比较不同治疗方法治疗子宫内膜腺癌的疗效。方法　386例患者分别给予以下3种不同的治疗方法，（1）单纯手术（手术组）145例；（2）手术+放射治疗(放疗，手术+放疗组）161例；（3）单纯放疗（放疗组）80例。治疗后随访均在5年以上，观察各组的5年生存率。结果　手术病理分期(放疗组为临床分期)Ⅰ期、Ⅱ期及Ⅲ～Ⅳ期的5年生存率，手术组分别为78.9%(56/71)、61.0%(25/41)及18.2%(6/33)；手术+放疗组分别为75.0%(33/44)、59.5%(44/74)及48.8%(21/43）；放疗组分别为34.8%(8/23)、18.8%(3/16)及0.0%(0/41)。Ⅰ期及Ⅱ期患者的5年生存率，手术组与手术+放疗组比较，差异无显著性（P>0.05)，而Ⅲ～Ⅳ期手术+放疗组明显高于手术组（P<0.001)；放疗组无论分期如何，其5年生存率均显著低于手术组和手术+放疗组（P<0.001)。结论　子宫内膜腺癌应尽量争取以手术为主的治疗，单纯放疗仅适于有手术禁忌证的患者。
목적　비교불동치료방법치료자궁내막선암적료효。방법　386례환자분별급여이하3충불동적치료방법，（1）단순수술（수술조）145례；（2）수술+방사치료(방료，수술+방료조）161례；（3）단순방료（방료조）80례。치료후수방균재5년이상，관찰각조적5년생존솔。결과　수술병리분기(방료조위림상분기)Ⅰ기、Ⅱ기급Ⅲ～Ⅳ기적5년생존솔，수술조분별위78.9%(56/71)、61.0%(25/41)급18.2%(6/33)；수술+방료조분별위75.0%(33/44)、59.5%(44/74)급48.8%(21/43）；방료조분별위34.8%(8/23)、18.8%(3/16)급0.0%(0/41)。Ⅰ기급Ⅱ기환자적5년생존솔，수술조여수술+방료조비교，차이무현저성（P>0.05)，이Ⅲ～Ⅳ기수술+방료조명현고우수술조（P<0.001)；방료조무론분기여하，기5년생존솔균현저저우수술조화수술+방료조（P<0.001)。결론　자궁내막선암응진량쟁취이수술위주적치료，단순방료부괄우유수술금기증적환자。
Objective　To compare the therapeutic effects of different remedis in patients with endometrial carcinoma. Methods　Total of 386 patients with metracarcinoma underwent 3 different treatments: (1) operation only 145 cases; (2) operation and complemental radiotherapy 161 cases; (3) radiotherapy only 80 cases. Then they were followed up for 5 years and more. Results　The 5-year survival rates of operation group were 78.9% (56/71), 61.0% (25/41) and 18.2% (6/33) in stage Ⅰ, stage Ⅱ, and stage Ⅲ～Ⅳ respectively, for operation and complemental radiotherapy,they were 75.0% (33/44), 59.5% (44/74) and 48.8% (21/43), for radiotherapy, 34.8% (8/23), 18.8% (3/16) and 0.0% (0/41). There was no difference between operation group and operation plus radiotherapy in patients with stage Ⅰ and stage Ⅱ (P>0.05). However the 5-year survival rates were significantly higher in operation plus complemental radiotherappy group and those only received operation in stage Ⅲ stage Ⅳ patients (P<0.001). And no matter in what stages, the therapeutic effect was worse in radiotherapy group than other two groups (P<0.001). Conclusion　The remedis with operation as main measure are the best choice for metracarcinoma, radiotherapy merely is fit with those who can not be operated on.