CAJ | 학술논문

基于近红外光纤漫反射技术,利用偏最小二乘法分别建立了复方氯丙那林胶囊的三种药效成分盐酸氯丙那林、盐酸溴己新和盐酸去氯羟嗪的快速同时测定方法.所建立的盐酸氯丙那林、盐酸溴己新和盐酸去氯羟嗪的定量分析多元校正模型的相关系数分别为99.7%、99.4%和99.0%,校正集的均方根残差分别为0.028、0.145和0.250,预测均方根误差分别为0.055、0.120和0.210.由于该方法是在不经任何预处理的情况下的光纤快速同时分析,因此可用于复方氯丙那林的过程质量控制.
기우근홍외광섬만반사기술,이용편최소이승법분별건립료복방록병나림효낭적삼충약효성분염산록병나림、염산추기신화염산거록간진적쾌속동시측정방법.소건립적염산록병나림、염산추기신화염산거록간진적정량분석다원교정모형적상관계수분별위99.7%、99.4%화99.0%,교정집적균방근잔차분별위0.028、0.145화0.250,예측균방근오차분별위0.055、0.120화0.210.유우해방법시재불경임하예처리적정황하적광섬쾌속동시분석,인차가용우복방록병나림적과정질량공제.
Based on the near infrared fiber diffuse reflectance spectroscopy,the analytical methods of the fast and simultaneous determinations for clorprenaline hydrochloride,bromhexine hydrochloride and decloxizine hydrochloride contained in the compound clorprenaline have been established by the partial least squares method.The multivariate calibration models for clorprenaline hydrochloride,bromhexine hydrochloride and decloxizine hydrochloride have the good correlations with the correlation coefficients of 99.7%,99.4% and 99.0%,and the root mean square errors of 0.028,0.145 and 0.250 for the calibration sample sets,and the strong prediction abilities with the root mean square errors of 0.055,0.120 and 0.210 for the prediction sample sets,respectively.Because of the fast and simultaneous fiber analyses with no pre-treating,the established method could be used in the process quality control of compound clorprenaline.