国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2009年
6期
521-523,528
,共4页
半胱氨酸%糖尿病,2型%肾小球滤过率
半胱氨痠%糖尿病,2型%腎小毬濾過率
반광안산%당뇨병,2형%신소구려과솔
Cysteine%Diabetes mellitus,type 2%Glomerular filtration rate
目的 研究血清同型半胱氨酸(Hcy)水平与2型糖尿病(T2DM)的关系,探讨影响T2DM患者血清Hcy水平的因素.方法 选择T2DM患者122例、慢性肾脏病(CKD)患者67例及健康对照(CON)50例,观察各组血清Hcy水平变化,并分析Hcy与预测肾小球滤过率(eGFR)、空腹血糖(FBG)、糖化血红蛋白(HbA1C)、尿素(Urea)、肌酐(CRE)之间的相关性.采用循环酶法测定血清Hey,离子交换高效液相法测定HbA1C,应用Levey改良的MDRD方程计算eGFR.结果 T2DM组血清Hcy与CON组相比差异无统计学意义(P＞0.05),CKD组血清Hcy显著高于T2DM组和CON组(P＜0.01).T2DM组中Hcy水平超过CON组95%上限者仪为8.20%,而CKD组中超过者为64.18%.T2DM组中肾功能止常者[eGFR≥90 mL·(rain·1.73 m2)-1]的Hcy水平与CON组比较差异无统计学意义(P＞0.05),肾功能异常者[eGFR＜90 mL·(min·1.73 m2)-1]的Hcy水平较CON组增高(P＜0.05).Hcy与eGFR在T2DM组和CKD组中均呈负相关(P＜0.01),与Ure-a、CRE呈正相关(P＜0.01),但Hcy与FBG、HbA1C、TC、TG均无相关性(P＞0.05).结论 糖尿病本身不会导致血中Hcy浓度增高,肾功能足影响T2DM患者Hcy水平的独立因素.
目的 研究血清同型半胱氨痠(Hcy)水平與2型糖尿病(T2DM)的關繫,探討影響T2DM患者血清Hcy水平的因素.方法 選擇T2DM患者122例、慢性腎髒病(CKD)患者67例及健康對照(CON)50例,觀察各組血清Hcy水平變化,併分析Hcy與預測腎小毬濾過率(eGFR)、空腹血糖(FBG)、糖化血紅蛋白(HbA1C)、尿素(Urea)、肌酐(CRE)之間的相關性.採用循環酶法測定血清Hey,離子交換高效液相法測定HbA1C,應用Levey改良的MDRD方程計算eGFR.結果 T2DM組血清Hcy與CON組相比差異無統計學意義(P＞0.05),CKD組血清Hcy顯著高于T2DM組和CON組(P＜0.01).T2DM組中Hcy水平超過CON組95%上限者儀為8.20%,而CKD組中超過者為64.18%.T2DM組中腎功能止常者[eGFR≥90 mL·(rain·1.73 m2)-1]的Hcy水平與CON組比較差異無統計學意義(P＞0.05),腎功能異常者[eGFR＜90 mL·(min·1.73 m2)-1]的Hcy水平較CON組增高(P＜0.05).Hcy與eGFR在T2DM組和CKD組中均呈負相關(P＜0.01),與Ure-a、CRE呈正相關(P＜0.01),但Hcy與FBG、HbA1C、TC、TG均無相關性(P＞0.05).結論 糖尿病本身不會導緻血中Hcy濃度增高,腎功能足影響T2DM患者Hcy水平的獨立因素.
목적 연구혈청동형반광안산(Hcy)수평여2형당뇨병(T2DM)적관계,탐토영향T2DM환자혈청Hcy수평적인소.방법 선택T2DM환자122례、만성신장병(CKD)환자67례급건강대조(CON)50례,관찰각조혈청Hcy수평변화,병분석Hcy여예측신소구려과솔(eGFR)、공복혈당(FBG)、당화혈홍단백(HbA1C)、뇨소(Urea)、기항(CRE)지간적상관성.채용순배매법측정혈청Hey,리자교환고효액상법측정HbA1C,응용Levey개량적MDRD방정계산eGFR.결과 T2DM조혈청Hcy여CON조상비차이무통계학의의(P＞0.05),CKD조혈청Hcy현저고우T2DM조화CON조(P＜0.01).T2DM조중Hcy수평초과CON조95%상한자의위8.20%,이CKD조중초과자위64.18%.T2DM조중신공능지상자[eGFR≥90 mL·(rain·1.73 m2)-1]적Hcy수평여CON조비교차이무통계학의의(P＞0.05),신공능이상자[eGFR＜90 mL·(min·1.73 m2)-1]적Hcy수평교CON조증고(P＜0.05).Hcy여eGFR재T2DM조화CKD조중균정부상관(P＜0.01),여Ure-a、CRE정정상관(P＜0.01),단Hcy여FBG、HbA1C、TC、TG균무상관성(P＞0.05).결론 당뇨병본신불회도치혈중Hcy농도증고,신공능족영향T2DM환자Hcy수평적독립인소.
Objective To study the relationship between serum level of homocysteic acid(Hcy)and type 2 diabetic mellitus(T2DM),and to explore the influencing factors serum for Hey level in T2DM patients.Methods Totally T2DM 122 patients(T2DM group),67 patients with chronic kidney diease(CKD group)and 50 healthy controls(CON group)were enrolled in the investigation.The variation of serum Hcy of all groups was observed,and the correlation of serum Hcy level with estimated glomerular filtration rate(eGFR),fasting serum glucose,HbA1C,Urea and creatinine was analyzed.Serum Hcy was measured by enzymatic cycling assay;HbA1C was measured by high-pressure liquid chromatography assay;and eGFR was calculated by using the Levey-modified Modification of Diet in Renal Disease formula.Results There was no significant difference in serum level of Hcy between T2DM group and CON group(P＞0.05).The serum concentration of Hey was significantly higher in CKD group than that of T2DM group and CON group(P＜0.01).There was only 8.20% exceeding the upper limit of 95% of CON group in T2DM group,while 64.18% exceeding the upper limit of 95% of CON group in CKD group.There was no significant difference of Hcy level between patients with eGFR≥90 mL·(min·1.73 m2)-1 in T2DM group and healthy controls(P＞0.05),but the Hey level was significantly higher in patients with eGFR＜90 mL·(min·1.73 m2)-1 than that of healthy controls(P＜0.05).In T2DM group and CKD group,serum Hey level was negatively correlative to eGFR(P＜0.01).positively correlative to Urea and creatinine(P＜0.01);but serum Hcy level did not correlate with fasting serum glucose,HbA1C,total cholesterol and triglyceride(P＞0.05).Conclusion Renal function is an independent risk factor for serum homocysteine level in type 2 diabetes rather than diabetes itself.
