中国药学(英文版)
中國藥學(英文版)
중국약학(영문판)
JOURNAL OF CHINESE PHARMACEUTICAL SCIENCES
2008年
4期
277-280
,共4页
闫旭%葛泽梅%程铁明%李润涛
閆旭%葛澤梅%程鐵明%李潤濤
염욱%갈택매%정철명%리윤도
1%3%4-噁二唑-5-硫醚%一锅煮合成%环境友好%水相%酰肼%磷酸钾
1%3%4-噁二唑-5-硫醚%一鍋煮閤成%環境友好%水相%酰肼%燐痠鉀
1%3%4-오이서-5-류미%일과자합성%배경우호%수상%선정%린산갑
1,3,4-Oxadiazole-5-thioether%One-pot synthesis%Environmental-friendly%Aqueous medium%Acylhydrazine%Potassium phosphate
此文报道了由酰肼,二硫化碳及卤代烃或α,β-不饱羰基化合物在水相中-锅煮反应合成1,3,4-噁二唑-5-硫醚类化合物的方法.该方法具有高效、反应条件温和、操作简单、适用范围广和环境友好等优点.
此文報道瞭由酰肼,二硫化碳及滷代烴或α,β-不飽羰基化閤物在水相中-鍋煮反應閤成1,3,4-噁二唑-5-硫醚類化閤物的方法.該方法具有高效、反應條件溫和、操作簡單、適用範圍廣和環境友好等優點.
차문보도료유선정,이류화탄급서대경혹α,β-불포탄기화합물재수상중-과자반응합성1,3,4-오이서-5-류미류화합물적방법.해방법구유고효、반응조건온화、조작간단、괄용범위엄화배경우호등우점.
An efficient and environmental-friendly one-pot procedure has been developed for the synthesis of 1,3,4-oxadiazole-5- thioethers by the reaction of acylhydrazine with carbon disulfide and organic halides or ct,13-unsaturated carbonyl compounds.The reactions were carried out in water in the presence of potassium phosphate within 2-4 h to afford the expected products in excellent yields.
