CAJ | 학술논문

目的研究哈尔滨市儿童期1型糖尿病与HLA-DQB1等位基因的关联关系.方法选取49例0～14岁发病的1型糖尿病患者和75名健康儿童对照,运用PCR-SSOP技术对部分HLA-DQB1等位基因进行了分型.结果发现在HLA-DQB1位点上,病例组的DQB1*0201、*0303、*0401频率显著高于对照组,而DQB1*0301、DQB1*0501和*0601频率是显著下降的.结论研究提示:HLA-DQB1位点的*0201、*0303和*0401对儿童期1型糖尿病具有强易感性,而DQB1*0301、*0501和*0601具有保护性.但未证实DQB1*0602具有保护性作用.
목적연구합이빈시인동기1형당뇨병여HLA-DQB1등위기인적관련관계.방법선취49례0～14세발병적1형당뇨병환자화75명건강인동대조,운용PCR-SSOP기술대부분HLA-DQB1등위기인진행료분형.결과발현재HLA-DQB1위점상,병례조적DQB1*0201、*0303、*0401빈솔현저고우대조조,이DQB1*0301、DQB1*0501화*0601빈솔시현저하강적.결론연구제시:HLA-DQB1위점적*0201、*0303화*0401대인동기1형당뇨병구유강역감성,이DQB1*0301、*0501화*0601구유보호성.단미증실DQB1*0602구유보호성작용.
Objective The association of HLA DQB1 alleles and type 1 diabetes in childhood (onset:0～14 years old) in Harbin was assessed.Methods PCR/SSOP typing method was used to identify HLA DQB1 alleles in the group of type 1 diabetes patients (n=49) and health controls (n=75).Results The frequencies of DQB1*0201,DQB1*0303 and DQB1*0401 were significantly increased in the patients than in control. But the frequencies of DQB1*0301,DQB1*0501 and DQB1*0601 in the patients were significantly decreased than in control.Conclusion The results suggested that DQB1*0201, DQB1*0303 and DQB1*0401 were the important susceptible alleles, DQB1*0301,DQB1*0501 and DQB10601 were important protective alleles. The resistance conferred by DQB1*0602 was not confirmed in Type 1 Diabetes in the children.