CAJ | 학술논문

目的：为研究TAP1基因和FcεRIβ基因多态性与哮喘及其表型的关系。方法：选择TAP1基因中微卫星DNA标志 TAP1及FcεRIβ基因中RFLP位点 RsaI，采用Amp-FIP和RFLP方法在散发哮喘病人中进行分析，并检测其血清总IgE水平，过敏原皮试及气道高反应性，应用相关分析观察TAP1及RsaI等位基因与哮喘及其表型的关系。结果：RsaI位点等位基因片段与哮喘及气道高反应性相关，未见TAP1与哮喘或其表型相关。结论：FcεRIβ基因可能是哮喘发病的一个候选基因，TAP1基因可能与哮喘的发病无关。
목적：위연구TAP1기인화FcεRIβ기인다태성여효천급기표형적관계。방법：선택TAP1기인중미위성DNA표지 TAP1급FcεRIβ기인중RFLP위점 RsaI，채용Amp-FIP화RFLP방법재산발효천병인중진행분석，병검측기혈청총IgE수평，과민원피시급기도고반응성，응용상관분석관찰TAP1급RsaI등위기인여효천급기표형적관계。결과：RsaI위점등위기인편단여효천급기도고반응성상관，미견TAP1여효천혹기표형상관。결론：FcεRIβ기인가능시효천발병적일개후선기인，TAP1기인가능여효천적발병무관。
Objective:In order to known the relationship between TAP1 gene, FcεRIβand the development of asthma.Methods:Themicrosatete TAP1 inside the intron of TAP1 gene and the RFLP locus inside the intron of FcεRIβgene were choiced to study in asthma patients using the Amp-FLP and RFLP method.Results: The allels of FcεRlβgene is associated with asthma and BHR, there is not relationship between TAP1 and asthma.Conchusion:FcεRIβgene may be important candidate gene susceptibility to asthma. TAP1 gene may not participate inthe devclopment of asthma.