CAJ | 학술논문

目的研究疟史对健康人和发热病人原虫血症的作用. 方法1989年5月和10月在中国云南省沧源县班老乡作了两次横断面调查.专业人员在对健康人采血、涂片、镜检的同时,进行问卷调查,调查内容包括疟史、性别、居住地海拔及村名5个方面.在4月和10月期间收集发热病人的情况,用EPI INFO 6.0和STATA 5.0软件对数据进行处理.结果单因素分析发现疟史和年龄是无症状带虫者[MLH比值比为3.98(95%可信限为2.48～6.40),年龄21～40的比值比为0.19(95%可信限为0.09～0.39),年龄≥40的比值比为0.38(95%可信限为0.16～0.90)]的危险因素.多因素分析发现年龄是混杂因素,冲淡了疟史的作用;而疟史是原虫血症发热病人的保护因素[比值比为0.37(95%可信限为0.21～0.65)].结论有疟史者很有可能是无症状的带虫者,是传播疟疾的传染源,应在早期阶段就对其重新治疗.疟史对健康人再次感染疟疾有抑制作用.单因素分析发现疟史和年龄是无症状带虫者[MLH比值比为3.98(95%可信限为2.48～6.40),年龄21～40的比值比为0.19(95%可信限为0.09～0.39),年龄≥40比值比为0.38(95%可信限为0.16～0.90)]的危险因素.多因素分析发现年龄是混杂因素,冲淡了疟史的作用;而疟史是原虫血症发热病人的保护因素[比值比为0.37(95%可信限为0.21～0.65)].结论有疟史者很有可能是无症状的带虫者,是传播疟疾的传染源,应在早期阶段就对其重新治疗.疟史对健康人再次感染疟疾有抑制作用.
목적연구학사대건강인화발열병인원충혈증적작용. 방법1989년5월화10월재중국운남성창원현반로향작료량차횡단면조사.전업인원재대건강인채혈、도편、경검적동시,진행문권조사,조사내용포괄학사、성별、거주지해발급촌명5개방면.재4월화10월기간수집발열병인적정황,용EPI INFO 6.0화STATA 5.0연건대수거진행처리.결과단인소분석발현학사화년령시무증상대충자[MLH비치비위3.98(95%가신한위2.48～6.40),년령21～40적비치비위0.19(95%가신한위0.09～0.39),년령≥40적비치비위0.38(95%가신한위0.16～0.90)]적위험인소.다인소분석발현년령시혼잡인소,충담료학사적작용;이학사시원충혈증발열병인적보호인소[비치비위0.37(95%가신한위0.21～0.65)].결론유학사자흔유가능시무증상적대충자,시전파학질적전염원,응재조기계단취대기중신치료.학사대건강인재차감염학질유억제작용.단인소분석발현학사화년령시무증상대충자[MLH비치비위3.98(95%가신한위2.48～6.40),년령21～40적비치비위0.19(95%가신한위0.09～0.39),년령≥40비치비위0.38(95%가신한위0.16～0.90)]적위험인소.다인소분석발현년령시혼잡인소,충담료학사적작용;이학사시원충혈증발열병인적보호인소[비치비위0.37(95%가신한위0.21～0.65)].결론유학사자흔유가능시무증상적대충자,시전파학질적전염원,응재조기계단취대기중신치료.학사대건강인재차감염학질유억제작용.
Objective To study the effect of malaria-like history as a risk factor on asymptomatic parasitaemia of healthy people and on symptomatic parasitaemia of febrile patients. Method Two cross-sectional studies were made in May and October of 1989 in Banlao Township, Cangyuan County, Yunnan, China. Blood sample slides were collected, stained and examined by professional staff, and information on malaria-like history, sex, age, elevation and village name were collected by interview using questionnaire while taking slides. Data on febrile patients were collected in April to October, 1989. Data were analyzed using Epi Info 6.0 and Stata 5.0. Results Malaria-like history (MLH) and age were the risk factors for asymptomatic parasitaemia of healthy people, with OR being 3.98 (95% CI 2.48-6.40) for MLH, and 0. 19 (95% CI 0. 09-0.39) for age 21-40 and 0. 38 (95% CI 0. 16-0.90) for age of ≥40. Age confounded and diluted the effect of MLH. MLH has effect on symptomatic parasitaemia of febrile patients, with OR being 0.37(95% CI 0.21-0. 65). Con- clusion These healthy people with MLH are more likely to be malaria parasite carriers and act as infection source of malari- a transmission. Effort should be made to retreat those people in early transmission stage. Those healthy people with MLH are less likely to be re-infected.