CAJ | 학술논문

目的　探讨糖尿病伴高血压患者24 h尿一氧化氮(NO)排量变化及其临床意义。方法　对46例糖尿病伴高血压病患者和64例无高血压的糖尿病患者进行24 h尿NO排量、血NO水平以及血、尿血管内皮素(ET)的测定，并与对照组作对照观察。结果　伴高血压的糖尿病组尿NO排量、血NO水平明显低于单纯糖尿病组，两者比较差异有显著性；但高于对照组,差异无显著性。单纯糖尿病组尿、血NO分别高于对照组，差异有显著性。结论　糖尿病伴高血压时尿NO变化与单纯糖尿病或非糖尿病的高血压病患者均有所不同，这既是糖尿病和高血压同时存在的结果，亦可能成为糖尿病和高血压并发症出现和发展的致病因素之一。
목적　탐토당뇨병반고혈압환자24 h뇨일양화담(NO)배량변화급기림상의의。방법 　대46례당뇨병반고혈압병환자화64례무고혈압적당뇨병환자진행24 h뇨NO배량、혈NO수평이급혈、뇨혈관내피소(ET)적측정，병여대조조작대조관찰。결과　반고혈압적당뇨병조뇨NO배량、혈NO수평명현저우단순당뇨병조，량자비교차이유현저성；단고우대조조,차이무현저성。단순당뇨병조뇨、혈NO분별고우대조조，차이유현저성。결론　당뇨병반고혈압시뇨NO변화여단순당뇨병혹비당뇨병적고혈압병환자균유소불동，저기시당뇨병화고혈압동시존재적결과，역가능성위당뇨병화고혈압병발증출현화발전적치병인소지일。
Objective　To determine the changing and its clinic significance of the quantity of the 24-hour urine NO release in diabetes patients with or without hypertention.Methods　We tested the quantity of 24-hour urine NO releasing,blood NO level, urine ET and blood ET level in 46 diabetes patients with hypertention and in 64 diabetes patients without hypertention and in control group.Results　The quantity of urine NO releasing, blood NO in diabetes patients with hypertention was significantly lower than the diabetes patients without hypertention and higher than control group.Conclusion　The changing of urine NO in diabetes with hypertention is different from the diabetes without hypertention and hypertention without diabetes. This is the results of the combination of diabetes and hypertention. It would become the risk factors of diabetes and complication,hypertention occurring and developing.