中国现代应用药学
中國現代應用藥學
중국현대응용약학
CONTENTS IN BRIEF
2001年
1期
57-59
,共3页
盐酸乙哌立松%高效液相色谱%托哌酮(内标)
鹽痠乙哌立鬆%高效液相色譜%託哌酮(內標)
염산을고립송%고효액상색보%탁고동(내표)
目的：建立高效液相色谱法测定盐酸乙哌立松片含量的方法。方法：盐酸乙哌立松片加甲醇、超声振荡、过滤后以ODS-C18为分析柱，以甲醇-水-三乙胺(80∶19.5∶0.5，V/V)为流动相，托哌酮为内标，于254nm波长检测。结果：盐酸乙哌立松在0.4～1.6mg/ml浓度范围内线性关系良好(r=0.9999)，平均回收率98.4%，RSD=1.2%。三批盐酸乙哌立松片含量测定结果分别为标示量的97.8%，98.3%和98.9%。结论：方法快速、准确、专一性强，适用于盐酸乙哌立松片的含量测定。
目的：建立高效液相色譜法測定鹽痠乙哌立鬆片含量的方法。方法：鹽痠乙哌立鬆片加甲醇、超聲振盪、過濾後以ODS-C18為分析柱，以甲醇-水-三乙胺(80∶19.5∶0.5，V/V)為流動相，託哌酮為內標，于254nm波長檢測。結果：鹽痠乙哌立鬆在0.4～1.6mg/ml濃度範圍內線性關繫良好(r=0.9999)，平均迴收率98.4%，RSD=1.2%。三批鹽痠乙哌立鬆片含量測定結果分彆為標示量的97.8%，98.3%和98.9%。結論：方法快速、準確、專一性彊，適用于鹽痠乙哌立鬆片的含量測定。
목적：건립고효액상색보법측정염산을고립송편함량적방법。방법：염산을고립송편가갑순、초성진탕、과려후이ODS-C18위분석주，이갑순-수-삼을알(80∶19.5∶0.5，V/V)위류동상，탁고동위내표，우254nm파장검측。결과：염산을고립송재0.4～1.6mg/ml농도범위내선성관계량호(r=0.9999)，평균회수솔98.4%，RSD=1.2%。삼비염산을고립송편함량측정결과분별위표시량적97.8%，98.3%화98.9%。결론：방법쾌속、준학、전일성강，괄용우염산을고립송편적함량측정。
OBJECTIVE：To develop a method for the determination of eperisone hydrochloride by high performance liquid chromatography(HPLC).METHOD:C18 column as the stationary phase and methanol-water-triethylamine(80∶19.5∶0.5,V/V,adjusted to pH 7.5 with glacial acetic acid) as the mobile phase were adopted.The detection was performed at 254nm.Eperisone hydrochloride tablets were disssolved in methanol,supersonic-vibrated and filtered.Tolperisone was used as internal standard.RESULTS:The standard curve was linear in the range of 0.4～1.6mg/ml with the excellent correlation coefficient of 0.9999.The average recovery was 98.4%(RSD=1.2%,n=15).Three batches of eperison hydrochloride tablets were analyzed and the labelled contents were 97.8%,98.3% and 98.9% respectively.CONCLUSION:The method was simple,sensitive,rapid and suitable for the quantitative anylysis of the preparation.
