CAJ | 학술논문

腹腔注射四氧嘧啶（ALX）200mg/kg建立糖尿病模型小鼠，并随机分为4组，分别用螺旋藻多糖（PSP）100mg/kg、200mg/kg及阳性对照药优降糖2mg/kg灌胃给药，糖尿病模型对照组则给等容积生理盐水，连续14d后，分别测定各组小鼠血糖、血清SOD活性、MDA含量及全血GSH-Px活性与GSH含量。结果与糖尿病模型对照组相比，PSP能使ALX所致糖尿病小鼠血糖降低（P<0.01）;血清SOD活性、全血GSH-Px活性及GSH含量显著回升（P<0.01）；血清MDA含量明显下降（P<0.01）。结果表明PSP能降低ALX性糖尿病小鼠高血糖并显著增强其抗氧化能力。提示PSP降血糖作用的机制可能与其增强糖尿病鼠抗氧化能力有关。
복강주사사양밀정（ALX）200mg/kg건립당뇨병모형소서，병수궤분위4조，분별용라선조다당（PSP）100mg/kg、200mg/kg급양성대조약우강당2mg/kg관위급약，당뇨병모형대조조칙급등용적생리염수，련속14d후，분별측정각조소서혈당、혈청SOD활성、MDA함량급전혈GSH-Px활성여GSH함량。결과여당뇨병모형대조조상비，PSP능사ALX소치당뇨병소서혈당강저（P<0.01）;혈청SOD활성、전혈GSH-Px활성급GSH함량현저회승（P<0.01）；혈청MDA함량명현하강（P<0.01）。결과표명PSP능강저ALX성당뇨병소서고혈당병현저증강기항양화능력。제시PSP강혈당작용적궤제가능여기증강당뇨병서항양화능력유관。
The diabetic model mice were established by intraperitonealinjection of alloxan(ALX) 200 mg/kg. Then the mice were randomly divided into four groups. Among them, two groups were given spirulina platensis polysach aride(PSP) 100mg/kg, 200 mg/kg respectively by ig administration, and one group was received Glibenclamide 2 mg/kg by ig adminstration as the positive control, another group was given normal saline as the diabetic model control. After 14 days anim als were killed to determine blood sugar, SOD, MDA, GSH-Px etc. It was found that PSP could obviously decrease the blood sugar, and significantly enhance the ac tivities of serum SOD and blood GSH-Px in diabetic mice induced by ALX. In addi t ion, the results also showed that PSP could remarkably decrease the content of serum MDA and greatly increase the concentration of blood GSH in the mice. It is suggested that PSP could decrease the level of blood sugar and effectively enhance the ability of anti-oxidation in the diabetic mice induced by ALX.