CAJ | 학술논문

目的：观察冠心病患者血浆小、密低密度脂蛋白(sdLDL)和脂类成分的变化及相互关系。方法：采用2％～16％非变性聚丙烯酰胺梯度胶电泳和凝胶成像分析，测定105例冠心病患者和76例健康对照者血浆sdLDL．同时测定血脂。结果：sdLDL>50％的检出率，冠心病组为38．1％，对照组为10．5％(P<0．001)；sdLDL增多患者的甘油三酯(TG)水平[(2．42±1．24)mmol／L]明显高于sdLDL正常者[(1．48±0．64)mmol／L](P<0．001)。结论：sdLDL与冠心病发生发展有关，且与TG关系密切；sdLDL测定可作为预测冠心病危险性的指标之一。
목적：관찰관심병환자혈장소、밀저밀도지단백(sdLDL)화지류성분적변화급상호관계。방법：채용2％～16％비변성취병희선알제도효전영화응효성상분석，측정105례관심병환자화76례건강대조자혈장sdLDL．동시측정혈지。결과：sdLDL>50％적검출솔，관심병조위38．1％，대조조위10．5％(P<0．001)；sdLDL증다환자적감유삼지(TG)수평[(2．42±1．24)mmol／L]명현고우sdLDL정상자[(1．48±0．64)mmol／L](P<0．001)。결론：sdLDL여관심병발생발전유관，차여TG관계밀절；sdLDL측정가작위예측관심병위험성적지표지일。
Objective: TO observe the interrelationship and change of small, dense low-density lipoprotein(sdLDL) and lipids from plasma of patients with coronary heart disease.Method:The sdLDL was examined using2%～ 16% nondenaturing polyacrylamide gradient gel electrophoresis and gel image acquisition analysis.meanwhile,the lipids were measured in 105 patients with coronary heart disease and 76 healthy controls. Result:The proportion of sdLDL>50% was significantly higher in patients with coronary heart disease than in healthycontrols (38.1% vs 10.5%. P <0.001). TG was higher in patients with increased sdLDL than those withnormal sdLDL,(2.42 ± 1.24 ) mmol/L vs (1.48±0.64) mmol/L,(P < 0. 001).Conclusion:The study suggeststhat there is a relationship between the presence of sdLDL and risk of developing coronary heart disease,sdLDLis associated with high concentrations of TG.The sdLDL is a predictable index of coronary heart disease risk.