CAJ | 학술논문

目的探讨Ⅱ型糖尿病患者胃液排空功能，同时观察西沙比利对糖尿病胃轻瘫的疗效。方法应用超声检查对22例正常组及20例糖尿病患者的胃液半排空时间进行比较，并用西沙比利（10 mg tid）治疗其中11名有胃轻瘫的病人，4周后复查对照。结果正常组胃液半排空间为（t1/2）（14.80±4.35）min，Ⅱ型糖尿病组的胃半排空时间为（28.00±8.94）min，二者之间有显著的差异。口服西沙比利后11名患者的胃半排空时间由（33.64±5.05）min减至（20.91±5.39）min。结论糖尿病患者胃排空有明显的障碍，西沙比利可改善糖尿病胃轻瘫，本实验为糖尿病人临床应用西沙比利治疗提供了理论依据。
목적 탐토Ⅱ형당뇨병환자위액배공공능，동시관찰서사비리대당뇨병위경탄적료효。방법 응용초성검사대22례정상조급20례당뇨병환자적위액반배공시간진행비교，병용서사비리（10 mg tid）치료기중11명유위경탄적병인，4주후복사대조。결과 정상조위액반배공간위（t1/2）（14.80±4.35）min，Ⅱ형당뇨병조적위반배공시간위（28.00±8.94）min，이자지간유현저적차이。구복서사비리후11명환자적위반배공시간유（33.64±5.05）min감지（20.91±5.39）min。결론 당뇨병환자위배공유명현적장애，서사비리가개선당뇨병위경탄，본실험위당뇨병인림상응용서사비리치료제공료이론의거。
Objective To investigate the gastric emptying function in patients with typeⅡdiabetic gastroparesis. Methods The gastric half-emptying time of liquid meals was measured by B-mode ultrasonography in 20 diabetic patients and 22 healthy subjects. Eleven diabetic patients with gastroparesis received cisapride at an oral single daily dose of 30 mg/d and were reexamined at the end of 4-week treatment course. Results The gastric half emptying time was (14.80±4.35) min in normal subjects and (28.00±8.94) min in diabetic patients. Significantly delayed gastric emptying was found in diabetic patients. The gastric half-emptying time was decreased from (33.64±5.05) min to (20.91±5.39) min (P<0.01) in 11 patients after cispride therapy. Conclusion The gastroparesis is common in patients with typeⅡ diabetes and cisapride has favorable effect on diabetic gastroparesis.