CAJ | 학술논문

肽聚糖是细菌细胞壁的重要成分,烯醇式丙酮酸转移酶(EPT)是调节肽聚糖合成初始阶段的关键酶.通过活性筛选,发现了三个对EPT有抑制活性的天然产物(化合物1～3),它们皆为EPT的新抑制剂.体外抗真菌实验发现,化合物2和3对光滑念珠菌具有较好的生长抑制作用.另外,化合物3还具有一定的肿瘤细胞毒活性.
태취당시세균세포벽적중요성분,희순식병동산전이매(EPT)시조절태취당합성초시계단적관건매.통과활성사선,발현료삼개대EPT유억제활성적천연산물(화합물1～3),타문개위EPT적신억제제.체외항진균실험발현,화합물2화3대광활념주균구유교호적생장억제작용.령외,화합물3환구유일정적종류세포독활성.
Bacterial enolpyruvyl transferase (EPT) is one of the key enzymes acting in the initial stage of peptidoglycan synthesis of bacterial cell walls. Through inhibition assay, three new natural inhibitors (1-3) were found against EPT. Inhibitor 2 and 3 showed antifungal activities against fungus Candida glabrata, and inhibitor 3 showed cytotoxicities against several cancer cells.