CAJ | 학술논문

成纤维细胞生长因子19( FGF19)是成纤维细胞生长因子家族中一个非典型的成员.FGF19除具有成纤维细胞生长因子的基本生理功能外,还可以通过增加肝糖原合成,减少肝糖原分解,改变肝脏中调节脂代谢的基因等途径发挥降低血糖、血脂,减轻体重,改善胰岛素敏感性的内分泌激素的功能.FGF19对糖、脂代谢的影响使其成为药物研究的一个新靶点.
성섬유세포생장인자19( FGF19)시성섬유세포생장인자가족중일개비전형적성원.FGF19제구유성섬유세포생장인자적기본생리공능외,환가이통과증가간당원합성,감소간당원분해,개변간장중조절지대사적기인등도경발휘강저혈당、혈지,감경체중,개선이도소민감성적내분비격소적공능.FGF19대당、지대사적영향사기성위약물연구적일개신파점.
Fibroblast growth factor 19(FGF19) is an atypical member of the fibroblast growth factor family.In addition to the basic physiological functions of fibroblast growth factor,FGF19 can act as an endocrine hormone to reduce blood glucose,blood lipid,weight and improve insulin sensitivity mainly in a way of increasing synthesis of liver glycogen,reducing decomposition liver glycogen,and changing the regulatory genes of lipid metabolism in liver.FGF19 affecting glucose and lipid metabolism makes it a new target of drug development.