CAJ | 학술논문

代谢组学是研究生物体的代谢浓度和流量的新兴科学,具有巨大的潜能和应用前景.目前代谢组学技术已应用于小儿神经系统遗传代谢性疾病的筛查,部分疾病得到临床治疗和缓解.该文综述了近年来代谢组学技术在小儿中枢神经系统感染性疾病早期鉴别诊断、神经系统脂质代谢异常的筛查及儿童孤独症等疾病的临床及实验研究的进展,特别是应用代谢组学技术发现神经元胆固醇贮积、糖代谢异常等,为神经系统脂类代谢异常疾病的临床诊断带来希望.
대사조학시연구생물체적대사농도화류량적신흥과학,구유거대적잠능화응용전경.목전대사조학기술이응용우소인신경계통유전대사성질병적사사,부분질병득도림상치료화완해.해문종술료근년래대사조학기술재소인중추신경계통감염성질병조기감별진단、신경계통지질대사이상적사사급인동고독증등질병적림상급실험연구적진전,특별시응용대사조학기술발현신경원담고순저적、당대사이상등,위신경계통지류대사이상질병적림상진단대래희망.
Metabolomics, the measurement of metabolite concentrations and fluxes in cell systems, is an emerging science that has enormous potential and good application prospect. Metabolomics technology, especially mass spectrometry, has been used extensively in screening children's heredity metabolic disease, and part of these diseases has become to be curing. In this review, we elaborate on the application of metabolomics in early diagnosis of central nervous system infectious disease, screening of lipide metabolism dysfunction in nervous system and childhood autism, with special focus on the finding of cholesterin storage in nerve cell, variations in the metabolism of glucose, which give its promise for diagnosis and treatment of the lipide metabolism dysfunction in nervous system.