CAJ | 학술논문

传染性单核细胞增多症/免疫学/代谢%T淋巴细胞/免疫学/代谢%T淋巴细胞亚群/免疫学/代谢%抗原,CD3/免疫学/代谢%抗原,CD43/免疫学/代谢%抗原,CD8/免疫学/代谢傳染性單覈細胞增多癥/免疫學/代謝%T淋巴細胞/免疫學/代謝%T淋巴細胞亞群/免疫學/代謝%抗原,CD3/免疫學/代謝%抗原,CD43/免疫學/代謝%抗原,CD8/免疫學/代謝
전염성단핵세포증다증/면역학/대사%T림파세포/면역학/대사%T림파세포아군/면역학/대사%항원,CD3/면역학/대사%항원,CD43/면역학/대사%항원,CD8/면역학/대사
Infectious mononucleosis/IM/ME%T-lymphocytes/IM/ME%T-lymphocyte subsets/IM/ME%Antigens,CD3/IM/ME%Antigens,CD4/IM/ME%Antigens,CD8/IM/ME

目的研究传染性单核细胞增多症(IM)患儿外周血CD3+CD4-CD8-T细胞(DNT细胞)及T淋巴细胞亚群变化及其临床意义.方法采用免疫荧光流式细胞技术检测了48例IM患儿及40例正常儿童外周血DNT细胞与T淋巴细胞亚群CD3+T细胞、CD3+CD4+T细胞及CD3+CD8+T细胞水平.结果 IM患儿DNT细胞百分比(9.39±4.89)%高于正常对照组(4.26±1.68)%(P＜0.01),CD3+CD4+T细胞百分比(21.45±9.87)%明显低于对照组(32.43±5.07)%(P＜0.01);而CD3+T细胞及CD3+CD8+T细胞百分比均明显高于对照组(P＜0.01).结论 IM患儿DNT细胞升高及T淋巴细胞亚群比例改变,提示IM患儿存在免疫功能异常,为IM患儿临床免疫治疗提供理论依据.
목적 연구전염성단핵세포증다증(IM)환인외주혈CD3+CD4-CD8-T세포(DNT세포)급T림파세포아군변화급기림상의의.방법 채용면역형광류식세포기술검측료48례IM환인급40례정상인동외주혈DNT세포여T림파세포아군CD3+T세포、CD3+CD4+T세포급CD3+CD8+T세포수평.결과 IM환인DNT세포백분비(9.39±4.89)%고우정상대조조(4.26±1.68)%(P＜0.01),CD3+CD4+T세포백분비(21.45±9.87)%명현저우대조조(32.43±5.07)%(P＜0.01);이CD3+T세포급CD3+CD8+T세포백분비균명현고우대조조(P＜0.01).결론 IM환인DNT세포승고급T림파세포아군비례개변,제시IM환인존재면역공능이상,위IM환인림상면역치료제공이론의거.
Objective To study on the changes of the DNT cells and T lymphocyte subtype in children with infectious mononucleosis (IM) and its clinical significance.Methods The flow cytometry (FCM) was used to detected the DNT cells and other T lymphocyte subtype in 48 cases of IM.Results The study showed that DNT cells( 9.39 ± 4.89 )% were greatly increased in comparison with normal controls (NC) (4.26 ± 1.68)% ( P ＜0.01 ).CD4 cells(21.45 ±9.87)% were decreased ( P ＜0.01 ) and CD8 cells increased in comparison with NC (32.43 ± 5.07) % ( P ＜ 0.01 ).Conclusion DNT cells and T lymphocyte subtype can be used to evaluate the immune function of children with infectious mononucleosis (IM) and provide guidance for adoptive immunotherapy.