CAJ | 학술논문

本文报道对乙基西梭霉素(NET)进行抗菌作用、正常人药代动力学和临床研究结果.本品对金葡菌等革兰氏阳性球菌(除肠球菌外)、肠杆菌科细菌和绿脓杆菌具较强抗菌活性,氨基糖类耐药菌株中部分对本品仍敏感.正常人肌注或静滴2mg/kg后血峰浓度分别为7.6±1.3mg/L和14.1±0.87mg/L,消除半衰期约为2h,24h内尿中排出85%.临床试用于各种感染50例,每日剂置3～6mg/kg,有效率90%,来见明显耳、肾毒性.对乙基西梭霉索的适应症和临床应用前景进行了探试 .
본문보도대을기서사매소(NET)진행항균작용、정상인약대동역학화림상연구결과.본품대금포균등혁란씨양성구균(제장구균외)、장간균과세균화록농간균구교강항균활성,안기당류내약균주중부분대본품잉민감.정상인기주혹정적2mg/kg후혈봉농도분별위7.6±1.3mg/L화14.1±0.87mg/L,소제반쇠기약위2h,24h내뇨중배출85%.림상시용우각충감염50례,매일제치3～6mg/kg,유효솔90%,래견명현이、신독성.대을기서사매색적괄응증화림상응용전경진행료탐시 .
A study on miorobiology,elinioal pharmacology and olmical effioaey and safety of netilmioin (NET),a new aminoglycoside,was undertaken.NET has good activity against S.aureus,other Gram positive cocci(except enterococci),Entarobaoteriaoeae and Ps aeruginosa and part of the strains resistant to other aminoglycosides.After Jan injeotion or iv infusion of 2mg/kg of NET to normal volunteers.the peak blood conoentrations were 7.6±1.31m g/L and 14.1±0.87mg/L respeokively.The elimination half life of both im and iv routes was around 2h,85% of the administered doseexcleted in urine within 24h. NET was given in a daily dosage of 3～6mg/kg to 50 patients with various infections,the total effective rate being 90%,no obvious oto-or nephro-toxieity was noted. The clinical indieation and prospoct of its usage are discussed.