中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
22期
4-6
,共3页
免疫球蛋白类%干扰素Ⅱ型%白细胞介素4%细菌溶解产物%孟鲁司特
免疫毬蛋白類%榦擾素Ⅱ型%白細胞介素4%細菌溶解產物%孟魯司特
면역구단백류%간우소Ⅱ형%백세포개소4%세균용해산물%맹로사특
Immunoglobulins%Interferon type Ⅱ%Interleukin-4%Bacterial lysates%Montelukast
目的 观察细菌溶解产物(泛福舒)联合孟鲁司特钠对哮喘患儿血清免疫球蛋白、干扰素γ(IFN-γ)及白细胞介素4(IL-4)的影响及临床疗效.方法 对31例急性发作期哮喘患儿(研究组)在常规治疗的基础上加用泛福舒与孟鲁司特钠,连用3个月.观察治疗前后血清IgG、IgA、IgM、IFN-γ和IL-4水平的变化,并与31例健康儿童(对照组)比较,同时观察研究组治疗前后日、夜间症状评分的变化.结果 研究组治疗前IgG和IgA明显异常(P<0.05),治疗后IgG和IgA均显著升高,但IgG仍然显著低于对照组,差异有统计学意义(P<0.05);治疗前IFN-γ及IL-4均明显异常(P<0.05),治疗后IFN-γ显著升高,IL-4则显著降低,差异均有统计学意义(P<0.05);治疗后,研究组日、夜间症状评分分别为(0.4±0.1)分和(0.7±0.2)分,均较治疗前的(2.6±0.3)分和(3.4±0.7)分显著下降,差异有统计学意义(P<0.05).结论 哮喘患儿存在机体免疫功能下降,泛福舒联合孟鲁司特钠可有效控制其症状并改善机体免疫状态.
目的 觀察細菌溶解產物(汎福舒)聯閤孟魯司特鈉對哮喘患兒血清免疫毬蛋白、榦擾素γ(IFN-γ)及白細胞介素4(IL-4)的影響及臨床療效.方法 對31例急性髮作期哮喘患兒(研究組)在常規治療的基礎上加用汎福舒與孟魯司特鈉,連用3箇月.觀察治療前後血清IgG、IgA、IgM、IFN-γ和IL-4水平的變化,併與31例健康兒童(對照組)比較,同時觀察研究組治療前後日、夜間癥狀評分的變化.結果 研究組治療前IgG和IgA明顯異常(P<0.05),治療後IgG和IgA均顯著升高,但IgG仍然顯著低于對照組,差異有統計學意義(P<0.05);治療前IFN-γ及IL-4均明顯異常(P<0.05),治療後IFN-γ顯著升高,IL-4則顯著降低,差異均有統計學意義(P<0.05);治療後,研究組日、夜間癥狀評分分彆為(0.4±0.1)分和(0.7±0.2)分,均較治療前的(2.6±0.3)分和(3.4±0.7)分顯著下降,差異有統計學意義(P<0.05).結論 哮喘患兒存在機體免疫功能下降,汎福舒聯閤孟魯司特鈉可有效控製其癥狀併改善機體免疫狀態.
목적 관찰세균용해산물(범복서)연합맹로사특납대효천환인혈청면역구단백、간우소γ(IFN-γ)급백세포개소4(IL-4)적영향급림상료효.방법 대31례급성발작기효천환인(연구조)재상규치료적기출상가용범복서여맹로사특납,련용3개월.관찰치료전후혈청IgG、IgA、IgM、IFN-γ화IL-4수평적변화,병여31례건강인동(대조조)비교,동시관찰연구조치료전후일、야간증상평분적변화.결과 연구조치료전IgG화IgA명현이상(P<0.05),치료후IgG화IgA균현저승고,단IgG잉연현저저우대조조,차이유통계학의의(P<0.05);치료전IFN-γ급IL-4균명현이상(P<0.05),치료후IFN-γ현저승고,IL-4칙현저강저,차이균유통계학의의(P<0.05);치료후,연구조일、야간증상평분분별위(0.4±0.1)분화(0.7±0.2)분,균교치료전적(2.6±0.3)분화(3.4±0.7)분현저하강,차이유통계학의의(P<0.05).결론 효천환인존재궤체면역공능하강,범복서연합맹로사특납가유효공제기증상병개선궤체면역상태.
Objective To observe the influence of bacterial lysates (broncho-vaxom) combined with montelukast sodium on serum immunoglobulin, interferon (IFN)-γ and interleukin (IL)-4 in asthma and the clinical efficacy. Methods Thirty-one patients with asthma in acute period of onset in children (study group) received broncho-vaxom combined with montelukast sodium for 3 months on the basis of conventional treatment. The changes of serum IgG, IgA, IgM, IFN-γ and IL-4 levels before and after treatment were observed and compared with 31 healthy children (control group), the score changes of day and night symptom were also observed before and after treatment. Results IgG and IgA levels were abnormal significantly in study group before treatment (P < 0.05 ), they were significantly increased after treatment, but IgG was still significantly lower than that in control group (P < 0.05 ). IFN-γ and IL-4 were significantly abnormal in study group before treatment (P < 0.05), IFN-γ was significantly increased after treatment (P<0.05), while IL-4 was significantly decreased (P<0.05); after 3 months of treatment, the score of day and night symptom in study group were (0.4±0.1 ) and (0.7±0.2) scores respectively, which both decreased significantly than those before treatment [(2.6±0.3 ) and (3.4±0.7) scores respectively],the difference were statistically significant(P < 0.05 ). Conclusion Children with asthma have the existence of decreased immune function, application of broncho-vaxom combined with montelukast sodium can effectively control its symptoms and improve immune status.
