CAJ | 학술논문

目的探讨MRI对鼻咽癌(NPC)放射治疗后的临床价值.方法 109例NPC患者在放疗前、放疗中及放疗后多次行MRI检查,对比分析治疗前后MRI表现的异同,以此评价NPC的放疗效果.所有病例均经病理活检或针吸细胞学检查或随访追踪证实.结果所有病例中,放疗前44例已发生颅底骨质侵犯;放疗开始1～2周可在放疗局部出现水肿,放疗后1个月局部水肿逐渐消退.65例病灶放疗后逐渐变小至完全消失;27例病灶在放疗过程中逐渐缩小,但放疗后6个月复查MRI示肿块又明显增大,其中12例出现颅底骨质破坏;17例放疗后病灶先是逐渐缩小,后多次复查MRI发现病灶呈团块状改变且形态相对固定,病理证实为纤维化;9例半年后复查MRI发现放射性脑损伤.结论 MRI检查可准确反应NPC放射治疗前后病灶变化情况,定期随访复查对于及时调整治疗方案具有重要参考价值.
목적 탐토MRI대비인암(NPC)방사치료후적림상개치.방법 109례NPC환자재방료전、방료중급방료후다차행MRI검사,대비분석치료전후MRI표현적이동,이차평개NPC적방료효과.소유병례균경병리활검혹침흡세포학검사혹수방추종증실.결과 소유병례중,방료전44례이발생로저골질침범;방료개시1～2주가재방료국부출현수종,방료후1개월국부수종축점소퇴.65례병조방료후축점변소지완전소실;27례병조재방료과정중축점축소,단방료후6개월복사MRI시종괴우명현증대,기중12례출현로저골질파배;17례방료후병조선시축점축소,후다차복사MRI발현병조정단괴상개변차형태상대고정,병리증실위섬유화;9례반년후복사MRI발현방사성뇌손상.결론 MRI검사가준학반응NPC방사치료전후병조변화정황,정기수방복사대우급시조정치료방안구유중요삼고개치.
Objective To explore the clinical values of MRI after radiotherapy for nasopharyngeal carcinoma(NPC). Methods One hundred and nine patients with NPC comfirmed by pathological biopsy or cytological smear or follow-up underwent MRI studies before,in the period of and after radiotherapy,and made a comparative analysis about differences of MRI manifestations before and after treatment, to evaluate radiotherapy effect for NPC depending on different appearances of MRI. Results Among all patients, there appeared to show violation of skull base bone in 44 patients before radiotherapy.Local edema appeared 1-2 weeks after radiotherapy started,and edema started to dissipate one month after treatment.The lesions became smaller and smaller,and dissipated in the end in 65 patients.The lesions became smaller and smaller in the period of radiotherapy in 27 patients,but six months later the lesions appeared larger, twelve cases of them were appeared violation of skull base bone.The lesions became smaller and smaller in the beginning,later fibrosis comfirmed by pathology in 17 patients. There appeared to show radiation encephalopathy following radiotherapy in 9 patients. Conclusions MRI can detect lesion changes before and after radiotherapy in NPC patients,and MRI plays an important role to adjust the treatment program timely by regular follow-up.